Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

doi:10.1088/1674-1056/27/2/028708

Abstract

Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid development of advanced technologies such as single-molecule technologies and cryo-electron microscopy (cryo-EM), an increasing number of their structural details and mechanics properties at molecular level have significantly raised awareness of basic life processes. In this review, firstly the basic principles of single-molecule method and cryo-EM are summarized, to shine a light on the development in these fields. Secondly, recent progress driven by the above two methods are underway to explore the dynamic structures and functions of DNA, antibody, and lipoprotein. Finally, an outlook is provided for the further research on both the dynamic structures and functions of bio-macromolecules, through single-molecule method and cryo-EM combining with molecular dynamics simulations.

Keywords: bio-macromolecule single-molecule method cryo-electron microscopy electron tomography

Received: 31 August 2017
Revised: 13 December 2017
Accepted manuscript online:

PACS:	87.64.Ee	(Electron microscopy)
	87.80.-y 87.15.B-
	87.15.H-	(Dynamics of biomolecules)

Fund:

Project supported by the National Basic Research Program of China (Grant No. 2015CB856304) and the National Natural Science Foundation of China (Grant Nos. 11504287 and 11774279).

Corresponding Authors: Lei Zhang
E-mail: zhangleio@mail.xjtu.edu.cn

About author: 87.64.Ee; 87.80.-y 87.15.B-; 87.15.H-

Cite this article:

Lu Gou(缑璐), Taoli Jin(金桃丽), Shuyu Chen(陈淑玉), Na Li(李娜), Dongxiao Hao(郝东晓), Shengli Zhang(张胜利), Lei Zhang(张磊) Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein 2018 Chin. Phys. B 27 028708

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[2]	Towards dynamic structure of biological complexes at atomic resolution by cryo-EM Kai Zhang(张凯). Chin. Phys. B, 2018, 27(6): 066801.
[3]	Computing methods for icosahedral and symmetry-mismatch reconstruction of viruses by cryo-electron microscopy Bin Zhu(朱彬), Lingpeng Cheng(程凌鹏), Hongrong Liu(刘红荣). Chin. Phys. B, 2018, 27(5): 056802.
[4]	Structural biology revolution led by technical breakthroughs in cryo-electron microscopy Chang-Cheng Yin(尹长城). Chin. Phys. B, 2018, 27(5): 058703.

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Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

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