Computational design of proteins with novel structure and functions

doi:10.1088/1674-1056/25/1/018702

Abstract

Computational design of proteins is a relatively new field, where scientists search the enormous sequence space for sequences that can fold into desired structure and perform desired functions. With the computational approach, proteins can be designed, for example, as regulators of biological processes, novel enzymes, or as biotherapeutics. These approaches not only provide valuable information for understanding of sequence-structure-function relations in proteins, but also hold promise for applications to protein engineering and biomedical research. In this review, we briefly introduce the rationale for computational protein design, then summarize the recent progress in this field, including de novo protein design, enzyme design, and design of protein-protein interactions. Challenges and future prospects of this field are also discussed.

Keywords: computational protein design de novo protein design enzyme design protein-protein interaction

Received: 15 May 2015
Accepted manuscript online:

PACS:	87.14.E-	(Proteins)
	87.15.km	(Protein-protein interactions)
	87.14.ej	(Enzymes)

Fund:

Project supported by the National Basic Research Program of China (Grant No. 2015CB910300), the National High Technology Research and Development Program of China (Grant No. 2012AA020308), and the National Natural Science Foundation of China (Grant No. 11021463).

Corresponding Authors: Lu-Hua Lai
E-mail: lhlai@pku.edu.cn

Cite this article:

Wei Yang(杨为) and Lu-Hua Lai(来鲁华) Computational design of proteins with novel structure and functions 2016 Chin. Phys. B 25 018702

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Computational design of proteins with novel structure and functions

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