Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer: in vitro study

doi:10.1088/1674-1056/ab84d4

Abstract This paper presents photoacoustic and ultrasonic dual-mode imaging for real-time detection of submucosal gastric cancer with a combination of gastroscopy. The diagnostic capacity was directly addressed via several phantoms and ex vivo experiments. Results demonstrated that superficial and submucosal gastric cancer can be diagnosed with a perceptible depth of 6.33 mm, a lateral accuracy of 2.23 mm, and a longitudinal accuracy of 0.17 mm though capturing the morphology of angiogenesis, which is a main character of the therioma-related change. The capability of gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging system will own great potential in improving the clinical diagnostic rate of submucosal gastric cancer.

Keywords: photoacoustic imaging intracavity pulsed laser irradiation extra abdominal receiving photoacoustic signal submucosal gastric cancer

Received: 29 January 2020
Revised: 24 February 2020
Accepted manuscript online:

PACS:	42.30.-d	(Imaging and optical processing)
	42.62.Be	(Biological and medical applications)
	43.35.+d	(Ultrasonics, quantum acoustics, and physical effects of sound)
	43.80.+p	(Bioacoustics)

Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 61675043, 81571726, and 81901787) and the Natural Science Foundation of Fujian Province, China (Grant Nos. 2018J01785 and 2018J01659).

Corresponding Authors: Hui Li
E-mail: hli@fjnu.edu.cn

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Huaqin Wu(吴华钦), Haiyang Song(宋海洋), Yudian Huang(黄玉钿), Zhifang Li(李志芳), Shulian Wu(吴淑莲), Xiaoman Zhang(章小曼), Hui Li(李晖) Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer: in vitro study 2020 Chin. Phys. B 29 064205

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Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer: in vitro study

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