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Chin. Phys. B, 2020, Vol. 29(6): 064205    DOI: 10.1088/1674-1056/ab84d4

Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer: in vitro study

Huaqin Wu(吴华钦)1, Haiyang Song(宋海洋)1, Yudian Huang(黄玉钿)2, Zhifang Li(李志芳)1, Shulian Wu(吴淑莲)1, Xiaoman Zhang(章小曼)1, Hui Li(李晖)1
1 College of Photonic and Electronic Engineering, Fujian Normal University, Fujian Provincial Engineering Research Center for OptoElectronic Sensing Technology, Fujian Provincial Key Laboratory of Photonic Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fuzhou 350007, China;
2 Department of Pathology, Fuzhou First Hospital Affiliated to Fujian Medical University, Fuzhou 350009, China
Abstract  This paper presents photoacoustic and ultrasonic dual-mode imaging for real-time detection of submucosal gastric cancer with a combination of gastroscopy. The diagnostic capacity was directly addressed via several phantoms and ex vivo experiments. Results demonstrated that superficial and submucosal gastric cancer can be diagnosed with a perceptible depth of 6.33 mm, a lateral accuracy of 2.23 mm, and a longitudinal accuracy of 0.17 mm though capturing the morphology of angiogenesis, which is a main character of the therioma-related change. The capability of gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging system will own great potential in improving the clinical diagnostic rate of submucosal gastric cancer.
Keywords:  photoacoustic imaging      intracavity pulsed laser irradiation      extra abdominal receiving photoacoustic signal      submucosal gastric cancer  
Received:  29 January 2020      Revised:  24 February 2020      Accepted manuscript online: 
PACS:  42.30.-d (Imaging and optical processing)  
  42.62.Be (Biological and medical applications)  
  43.35.+d (Ultrasonics, quantum acoustics, and physical effects of sound)  
  43.80.+p (Bioacoustics)  
Fund: Project supported by the National Natural Science Foundation of China (Grant Nos. 61675043, 81571726, and 81901787) and the Natural Science Foundation of Fujian Province, China (Grant Nos. 2018J01785 and 2018J01659).
Corresponding Authors:  Hui Li     E-mail:

Cite this article: 

Huaqin Wu(吴华钦), Haiyang Song(宋海洋), Yudian Huang(黄玉钿), Zhifang Li(李志芳), Shulian Wu(吴淑莲), Xiaoman Zhang(章小曼), Hui Li(李晖) Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer: in vitro study 2020 Chin. Phys. B 29 064205

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