Dynamic instability of collective myosin II motors

doi:10.1088/1674-1056/25/11/118701

Abstract Some kinds of muscles can oscillate spontaneously, which is related to the dynamic instability of the collective motors. Based on the two-state ratchet model and with consideration of the motor stiffness, the dynamics of collective myosin Ⅱ motors are studied. It is shown that when the motor stiffness is small, the velocity of the collective motors decreases monotonically with load increasing. When the motor stiffness becomes large, dynamic instability appears in the force-velocity relationship of the collective-motor transport. For a large enough motor stiffness, the zero-velocity point lies in the unstable range of the force-velocity curve, and the motor system becomes unstable before the motion is stopped, so spontaneous oscillations can be generated if the system is elastically coupled to its environment via a spring. The oscillation frequency is related to the motor stiffness, motor binding rate, spring stiffness, and the width of the ATP excitation interval. For a medium motor stiffness, the zero-velocity point lies outside the unstable range of the force-velocity curve, and the motion will be stopped before the instability occurs.

Keywords: ratchet model motor stiffness dynamic instability spontaneous oscillation

Received: 11 May 2016
Revised: 05 July 2016
Accepted manuscript online:

PACS:

87.16.Nn

(Motor proteins (myosin, kinesin dynein))

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11205123).

Corresponding Authors: Zi-Qing Wang
E-mail: zqwang@nwafu.edu.cn

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Jin-Fang Li(李金芳), Zi-Qing Wang(汪自庆), Qi-Kun Li(李奇昆), Jian-Jun Xing(邢建军), Guo-Dong Wang(王国栋) Dynamic instability of collective myosin II motors 2016 Chin. Phys. B 25 118701

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