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Chinese Physics, 2007, Vol. 16(9): 2587-2594    DOI: 10.1088/1009-1963/16/9/015
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Dynamics of network motifs in genetic regulatory networks

Li Ying(李莹)a)†, Liu Zeng-Rong(刘曾荣)b)‡, and Zhang Jian-Bao(张建宝)a)
a Department of Mathematics, Shanghai University, Shanghai 200444, China; b Institute of Systems Biology, Shanghai University, Shanghai 200444, China
Abstract  Network motifs hold a very important status in genetic regulatory networks. This paper aims to analyse the dynamical property of the network motifs in genetic regulatory networks. The main result we obtained is that the dynamical property of a single motif is very simple with only an asymptotically stable equilibrium point, but the combination of several motifs can make more complicated dynamical properties emerge such as limit cycles. The above-mentioned result shows that network motif is a stable substructure in genetic regulatory networks while their combinations make the genetic regulatory network more complicated.
Keywords:  genetic regulatory network      motif      feedback loop  
Received:  06 January 2007      Revised:  19 March 2007      Accepted manuscript online: 
PACS:  05.45.-a (Nonlinear dynamics and chaos)  
  02.60.Cb (Numerical simulation; solution of equations)  
  87.18.Sn (Neural networks and synaptic communication)  
Fund: Project supported by the National Natural Science Foundation of China (Grant No~10672093) and Innovation Foundation of Shanghai University for Postgraduates, China. %, 70431002,10672093).

Cite this article: 

Li Ying(李莹), Liu Zeng-Rong(刘曾荣), and Zhang Jian-Bao(张建宝) Dynamics of network motifs in genetic regulatory networks 2007 Chinese Physics 16 2587

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