Wideband frequency-dependent dielectric properties of rat tissues exposed to low-intensity focused ultrasound in the microwave frequency range
Xue Wang(王雪)1,2, Shi-Xie Jiang3, Lin Huang(黄林)2, Zi-Hui Chi(迟子惠)1, Dan Wu(吴丹)1, and Hua-Bei Jiang4,†
1 School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China; 2 School of Electronic Science and Engineering(National Exemplary School of Microelectronics), University of Electronic Science and Technology of China, Chengdu 611731, China; 3 Department of Psychiatry&Behavioral Neurosciences, University of South Florida, Tampa 33613, USA; 4 Department of Medical Engineering, University of South Florida, Tampa 33620, USA
Abstract Tissue dielectric properties can vary upon the incident of an acoustic wave. The goal of this study is to quantify this change due to the acoustoelectric effect (AE), and to obtain the frequency-dependent dielectric properties of tissues exposed to low-intensity focused ultrasound (LIFU). The dielectric properties of the blood, brain, chest muscle, heart, kidney, leg muscle, liver, lung, pancreas, and spleen of rats were measured by an open-ended coaxial probe method. The acoustic intensity of LIFU focus was 2.97 MPa (67.6 W/cm2), 3.95 MPa (120 W/cm2), and 5.17 MPa (204 W/cm2), respectively, and the measurement frequency band was 0.1-7.08 GHz. The measurement results show that with the LIFU modulation, the conductivity and dielectric constant decreased in the high-frequency band, and on the contrary, they increased in the low-frequency band, and the larger the acoustic intensity was, the more obvious the phenomenon was. This work contributes to a better understanding of the mechanisms by which ultrasound acts on the dielectric properties of biological tissues. It is expected that the findings from this study will provide a basis that the response of tissue to LIFU modulation can be monitored by noninvasive techniques such as microwave-induced thermoacoustic imaging (MTI) and microwave imaging, present a new idea for improving the endogenous contrast between different biological tissues in MTI and acoustoelectric imaging, and possibly lead to the development of a new imaging method based on the relaxation time of tissue after LIFU modulation.
(Biological effects of ultrasound, ultrasonic tomography)
Fund: Project partially supported by the National Natural Science Foundation of China (Grant Nos. 82071940 and 62001075) and Chongqing Municipal Education Commission Youth Fund, China (Grant Nos. KJQN20200607 and KJQN20200610).
Xue Wang(王雪), Shi-Xie Jiang, Lin Huang(黄林), Zi-Hui Chi(迟子惠), Dan Wu(吴丹), and Hua-Bei Jiang Wideband frequency-dependent dielectric properties of rat tissues exposed to low-intensity focused ultrasound in the microwave frequency range 2023 Chin. Phys. B 32 034305
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