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Chin. Phys. B, 2018, Vol. 27(2): 028705    DOI: 10.1088/1674-1056/27/2/028705
Special Issue: SPECIAL TOPIC — Soft matter and biological physics
SPECIAL TOPIC—Soft matter and biological physics Prev   Next  

Diffusional inhomogeneity in cell cultures

Jia-Zheng Zhang(张佳政), Na Li(李娜), Wei Chen(陈唯)
State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China
Abstract  Cell migrations in the cell cultures are found to follow non-Gaussian statistics. We recorded long-term cell migration patterns with more than six hundred cells located in 28 mm2. Our experimental data support the claim that an individual cell migration follows Gaussian statistics. Because the cell culture is inhomogeneous, the statistics of the cell culture exhibit a non-Gaussian distribution. We find that the normalized histogram of the diffusion velocity follows an exponential tail. A simple model is proposed based on the diffusional inhomogeneity to explain the exponential distribution of locomotion activity in this work. Using numerical calculation, we prove that our model is in great agreement with the experimental data.
Keywords:  random walks      cell locomotion      collective behavior  
Received:  31 August 2017      Revised:  10 November 2017      Accepted manuscript online: 
PACS:  87.17.Jj (Cell locomotion, chemotaxis)  
  05.40.Fb (Random walks and Levy flights)  
  87.18.Gh (Cell-cell communication; collective behavior of motile cells)  
Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11474054).
Corresponding Authors:  Wei Chen     E-mail:  phchenwei@fudan.edu.cn
About author:  87.17.Jj; 05.40.Fb; 87.18.Gh

Cite this article: 

Jia-Zheng Zhang(张佳政), Na Li(李娜), Wei Chen(陈唯) Diffusional inhomogeneity in cell cultures 2018 Chin. Phys. B 27 028705

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