Special Issue:
SPECIAL TOPIC — Soft matter and biological physics
|
SPECIAL TOPIC—Soft matter and biological physics |
Prev
Next
|
|
|
Diffusional inhomogeneity in cell cultures |
Jia-Zheng Zhang(张佳政), Na Li(李娜), Wei Chen(陈唯) |
State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China |
|
|
Abstract Cell migrations in the cell cultures are found to follow non-Gaussian statistics. We recorded long-term cell migration patterns with more than six hundred cells located in 28 mm2. Our experimental data support the claim that an individual cell migration follows Gaussian statistics. Because the cell culture is inhomogeneous, the statistics of the cell culture exhibit a non-Gaussian distribution. We find that the normalized histogram of the diffusion velocity follows an exponential tail. A simple model is proposed based on the diffusional inhomogeneity to explain the exponential distribution of locomotion activity in this work. Using numerical calculation, we prove that our model is in great agreement with the experimental data.
|
Received: 31 August 2017
Revised: 10 November 2017
Accepted manuscript online:
|
PACS:
|
87.17.Jj
|
(Cell locomotion, chemotaxis)
|
|
05.40.Fb
|
(Random walks and Levy flights)
|
|
87.18.Gh
|
(Cell-cell communication; collective behavior of motile cells)
|
|
Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11474054). |
Corresponding Authors:
Wei Chen
E-mail: phchenwei@fudan.edu.cn
|
About author: 87.17.Jj; 05.40.Fb; 87.18.Gh |
Cite this article:
Jia-Zheng Zhang(张佳政), Na Li(李娜), Wei Chen(陈唯) Diffusional inhomogeneity in cell cultures 2018 Chin. Phys. B 27 028705
|
[1] |
Berg H C and Purcell E M 1977 Biophys. J. 20 193
|
[2] |
Czirok A, Schlett K, Madarasz E and Vicsek T 1998 Phys. Rev. Lett. 81 3038
|
[3] |
Couzin I D and Krause J 2003 Adv. Study Behav. 32 1
|
[4] |
Ni R, Puckett J G, DUfresne E R and Ouellette N T 2015 Phys. Rev. Lett. 115 118104
|
[5] |
Nourhani A, Crespi V H and Lammert P E 2014 Phys. Rev. B 89 062304
|
[6] |
Maree A F M and Hogeweg P 2014 Proc. Natl. Acad. Sci. USA 98 3879
|
[7] |
Varnum B and Soll D R 2014 J. Cell Biol. 99 1151
|
[8] |
He W, Song H, Su Y, Geng L, Ackerson B J, Peng H B and Tong P 2016 Nat. Commun. 7 11701
|
[9] |
Li L, Norrelykke S F and Cox E C 2008 Plos One 3 e2093
|
[10] |
Dieterich P, Klages R, Preuss R and Schwab A 2008 Proc. Natl. Acad. Sci. USA 105 459
|
[11] |
Takagi H, Sato M J, Yanagida T and Ueda M 2008 Plos One 3 e2648
|
[12] |
Shenderove A D and Sheetz M P 1997 Biolphys. J. 72 2382
|
[13] |
Viswanathan G M, Afanasyev V, Buldyrev S V, Havlin S, da Luz M G E, Raposo E P and Stanley H E 1999 Nature 401 911
|
[14] |
Viswanathan G M, Bartumeus F, Buldyrev S V, Catalan J,Fulco U L, Havlin S, da Luz M G E, Lyra M L, Raposo E P and Stanley H E 2002 Physica A 314 208
|
[15] |
Reynolds A 2002 J. Plrev. 14 59
|
[16] |
Chen S, Li N, Hsu S F, Zhang J Z, Lai P Y, Chan C K and Chen W 2014 Soft Matter 10 3421
|
[17] |
Uhlenbeck G E and Ornstein L S 1930 Phys. Rev. 36 823
|
No Suggested Reading articles found! |
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
Altmetric
|
blogs
Facebook pages
Wikipedia page
Google+ users
|
Online attention
Altmetric calculates a score based on the online attention an article receives. Each coloured thread in the circle represents a different type of online attention. The number in the centre is the Altmetric score. Social media and mainstream news media are the main sources that calculate the score. Reference managers such as Mendeley are also tracked but do not contribute to the score. Older articles often score higher because they have had more time to get noticed. To account for this, Altmetric has included the context data for other articles of a similar age.
View more on Altmetrics
|
|
|