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Special Issue:
TOPICAL REVIEW — Magnetism, magnetic materials, and interdisciplinary research
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| TOPICAL REVIEW—Magnetism, magnetic materials, and interdisciplinary research |
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Toxicity of superparamagnetic iron oxide nanoparticles：Research strategies and implications for nanomedicine |
| Li Lei (李蕾)a, Jiang Ling-Ling (江玲玲)a, Zeng Yun (曾云)a b, Liu Gang (刘刚)a |
a Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China;
b Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong 637007, China |
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Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.
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Received: 13 September 2013
Accepted manuscript online:
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PACS:
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75.50.-y
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(Studies of specific magnetic materials)
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87.85.J-
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(Biomaterials)
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87.85.jj
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(Biocompatibility)
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87.85.Rs
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(Nanotechnologies-applications)
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| Fund: Project supported by the Major State Basic Research Development Program of China (Grant Nos. 2013CB733802 and 2014CB744503), the National Natural Science Foundation of China (Grant Nos. 81101101 and 51273165), the Key Project of Chinese Ministry of Education (Grant No. 212149), and the Fundamental Research Funds for the Central Universities, China (Grant Nos. 2013121039 and ZK1002). |
Corresponding Authors:
Liu Gang
E-mail: gangliu.cmitm@xmu.edu.cn
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Cite this article:
Li Lei (李蕾), Jiang Ling-Ling (江玲玲), Zeng Yun (曾云), Liu Gang (刘刚) Toxicity of superparamagnetic iron oxide nanoparticles：Research strategies and implications for nanomedicine 2013 Chin. Phys. B 22 127503
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