Enhanced effect of dimension of receptor-ligand complex and depletion effect on receptor-mediated endocytosis of nanoparticles

doi:10.1088/1674-1056/26/12/128704

Abstract

We present an extended analytical model including the depletion effect and the dimension of ligand-receptor complex, aiming to elucidate their influences on endocytosis of spherocylindrical nanoparticles (NPs). It is found that the dimension of ligand-receptor complex (δ) and the depletion effect interrelatedly govern the optimal conditions of NP endocytosis. The endocytosis phase diagram constructed in the space of NP radius and relative aspect ratio indicates that the endocytosis of NP is enhanced evidently by reducing the optimal radius and the threshold radius of endocytosed NP. Meanwhile, through thermodynamic and kinetic analysis of the diffusion of receptors, the dependence of diffusion length on depletion effect and the dimension of ligand-receptor complex can be identified in great detail. For small aspect ratio, diffusion length decreases with increasing concentration c of small bioparticles in cellular environment. Endocytosis speed corresponding to large radius R and high concentration c of small bioparticles strongly depends on the increasing (2r-δ). These results may show some highlights into the conscious design of NPs for diagnostic agents and therapeutic drug delivery applications.

Keywords: cellular uptake depletion effect dimension of receptor-ligand complex elasticity theory

Received: 24 August 2017
Revised: 10 October 2017
Accepted manuscript online:

PACS:	87.10.Pq	(Elasticity theory)
	87.16.A-	(Theory, modeling, and simulations)
	87.17.Rt	(Cell adhesion and cell mechanics)

Fund:

Project supported by the National Natural Science Foundation of China (Grant Nos. 11047022, 11204045, and 11464004), the Tracking Key Program of Social Development of Guizhou Province, China (Grant Nos. SY20123089 and SZ20113069), the General Financial Grant from the China Postdoctoral Science Foundation (Grant No. 2014M562341), the Research Foundation for Young University Teachers from Guizhou University (Grant No. 201311), and the College Innovation Talent Team of Guizhou Province, China (Grant No. (2014)32).

Corresponding Authors: Lin Hu, Yanhui Liu
E-mail: hulin53@sina.com;ionazati@itp.ac.cn

Cite this article:

Ye Liu(刘野), Qingqing Gao(高庆庆), Yijun Liu(刘益军), Chuang Zhao(赵闯), Zongliang Mao(毛宗良), Lin Hu(胡林), Yanhui Liu(刘艳辉) Enhanced effect of dimension of receptor-ligand complex and depletion effect on receptor-mediated endocytosis of nanoparticles 2017 Chin. Phys. B 26 128704

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Enhanced effect of dimension of receptor-ligand complex and depletion effect on receptor-mediated endocytosis of nanoparticles

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