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Chin. Phys. B, 2015, Vol. 24(12): 128711    DOI: 10.1088/1674-1056/24/12/128711
INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY Prev   Next  

Linear-fitting-based similarity coefficient map for tissue dissimilarity analysis in T2*-w magnetic resonance imaging

Yu Shao-De (余绍德)a b, Wu Shi-Bin (伍世宾)a b, Wang Hao-Yu (王浩宇)c, Wei Xin-Hua (魏新华)d, Chen Xin (陈鑫)d, Pan Wan-Long (潘万龙)e, Hu Jianif, Xie Yao-Qin (谢耀钦)a
a Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing 100049, China;
d Department of Radiology, Guangzhou First Hospital, Guangzhou 510080, China;
e Institute of Medical Imaging, North Sichuan Medical University, Nanchong 637007, China;
f Department of Radiology, Wayne State University, Detroit 48201, USA
Abstract  Similarity coefficient mapping (SCM) aims to improve the morphological evaluation of T2* weighted magnetic resonance imaging (T2*-w MRI). However, how to interpret the generated SCM map is still pending. Moreover, is it probable to extract tissue dissimilarity messages based on the theory behind SCM? The primary purpose of this paper is to address these two questions. First, the theory of SCM was interpreted from the perspective of linear fitting. Then, a term was embedded for tissue dissimilarity information. Finally, our method was validated with sixteen human brain image series from multi-echo T2*-w MRI. Generated maps were investigated from signal-to-noise ratio (SNR) and perceived visual quality, and then interpreted from intra- and inter-tissue intensity. Experimental results show that both perceptibility of anatomical structures and tissue contrast are improved. More importantly, tissue similarity or dissimilarity can be quantified and cross-validated from pixel intensity analysis. This method benefits image enhancement, tissue classification, malformation detection and morphological evaluation.
Keywords:  T2*-w magnetic resonance imaging      similarity coefficient map      linear fitting      tissue dissimilarity  
Received:  03 April 2015      Revised:  04 August 2015      Accepted manuscript online: 
PACS:  87.61.-c (Magnetic resonance imaging)  
  87.57.C- (Image quality)  
  02.10.Ud (Linear algebra)  
Fund: Project supported in part by the National High Technology Research and Development Program of China (Grant Nos. 2015AA043203 and 2012AA02A604), the National Natural Science Foundation of China (Grant Nos. 81171402, 61471349, and 81501463), the Innovative Research Team Program of Guangdong Province, China (Grant No. 2011S013), the Science and Technological Program for Higher Education, Science and Research, and Health Care Institutions of Guangdong Province, China (Grant No. 2011108101001), the Natural Science Foundation of Guangdong Province, China (Grant No. 2014A030310360), the Fundamental Research Program of Shenzhen City, China (Grant No. JCYJ20140417113430639), and Beijing Center for Mathematics and Information Interdisciplinary Sciences, China.
Corresponding Authors:  Xie Yao-Qin     E-mail:  yq.xie@siat.ac.cn

Cite this article: 

Yu Shao-De (余绍德), Wu Shi-Bin (伍世宾), Wang Hao-Yu (王浩宇), Wei Xin-Hua (魏新华), Chen Xin (陈鑫), Pan Wan-Long (潘万龙), Hu Jiani, Xie Yao-Qin (谢耀钦) Linear-fitting-based similarity coefficient map for tissue dissimilarity analysis in T2*-w magnetic resonance imaging 2015 Chin. Phys. B 24 128711

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