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The structural analysis of protein sequences based on the quasi-amino acids code
朱平, 唐旭清, 徐振源
2009 (1):
363-369.
doi: 10.1088/1674-1056/18/1/059
摘要
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Proteomics is the study of proteins and their interactions in a
cell. With the successful completion of the Human Genome Project, it
comes the postgenome era when the proteomics technology is emerging.
This paper studies protein molecule from the algebraic point of
view. The algebraic system (∑,+,*) is introduced,
where ∑ is the set of 64 codons. According to the
characteristics of (∑,+,*), a novel quasi-amino
acids code classification method is introduced and the corresponding
algebraic operation table over the set ZU of the 16 kinds of
quasi-amino acids is established. The internal relation is revealed
about quasi-amino acids. The results show that there exist some very
close correlations between the properties of the quasi-amino acids and
the codon. All these correlation relationships may play an important
part in establishing the logic relationship between codons and the
quasi-amino acids during the course of life origination. According
to Ma F et al (2003 J. Anhui Agricultural University
30 439), the corresponding relation and the excellent
properties about amino acids code are very difficult to observe. The
present paper shows that (ZU, ⊕,○x) is a field.
Furthermore, the operational results display that the codon tga
has different property from other stop codons. In fact, in the
mitochondrion from human and ox genomic codon, tga is just
tryptophane, is not the stop codon like in other genetic code, it is
the case of the Chen W C et al (2002 Acta Biophysica
Sinica 18(1) 87). The present theory avoids some
inexplicable events of the 20 kinds of amino acids code, in other
words it solves the problem of `the 64 codon assignments of mRNA to
amino acids is probably completely wrong' proposed by Yang
(2006 Progress in Modern Biomedicine 6 3).
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