中国物理B ›› 2017, Vol. 26 ›› Issue (1): 10701-010701.doi: 10.1088/1674-1056/26/1/010701

• GENERAL • 上一篇    下一篇

Ultralow detection limit of giant magnetoresistance biosensor using Fe3O4-graphene composite nanoparticle label

Jie Xu(徐洁), Ji-qing Jiao(焦吉庆), Qiang Li(李强), Shan-dong Li(李山东)   

  1. 1. College of Physics, Key Laboratory of Photonics Materials and Technology in Universities of Shandong, and Laboratory of Fiber Materials and Modern Textile, the Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China;
    2. School of Chemical Science and Engineering, Qingdao University, Qingdao 266071, China;
    3. National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China
  • 收稿日期:2016-05-14 修回日期:2016-09-13 出版日期:2017-01-05 发布日期:2017-01-05
  • 通讯作者: Shan-dong Li E-mail:lishd@qdu.edu.cn
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11074040, 11504192, 11674187, 11604172, and 51403114), the Natural Science Foundation of Shandong Province, China (Grant Nos. ZR2012FZ006 and BS2014CL010), and the China Postdoctoral Science Foundation (Grant Nos. 2014M551868 and 2015M570570).

Ultralow detection limit of giant magnetoresistance biosensor using Fe3O4-graphene composite nanoparticle label

Jie Xu(徐洁)1,2, Ji-qing Jiao(焦吉庆)2, Qiang Li(李强)1, Shan-dong Li(李山东)1,3   

  1. 1. College of Physics, Key Laboratory of Photonics Materials and Technology in Universities of Shandong, and Laboratory of Fiber Materials and Modern Textile, the Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China;
    2. School of Chemical Science and Engineering, Qingdao University, Qingdao 266071, China;
    3. National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China
  • Received:2016-05-14 Revised:2016-09-13 Online:2017-01-05 Published:2017-01-05
  • Contact: Shan-dong Li E-mail:lishd@qdu.edu.cn
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11074040, 11504192, 11674187, 11604172, and 51403114), the Natural Science Foundation of Shandong Province, China (Grant Nos. ZR2012FZ006 and BS2014CL010), and the China Postdoctoral Science Foundation (Grant Nos. 2014M551868 and 2015M570570).

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摘要： A special Fe3O4 nanoparticles-graphene (Fe3O4-GN) composite as a magnetic label was employed for biodetection using giant magnetoresistance (GMR) sensors with a Wheatstone bridge. The Fe3O4-GN composite exhibits a strong ferromagnetic behavior with the saturation magnetization MS of approximately 48 emu/g, coercivity HC of 200 Oe, and remanence Mr of 8.3 emu/g, leading to a large magnetic fringing field. However, the Fe3O4 nanoparticles do not aggregate together, which can be attributed to the pinning and separating effects of graphene sheet to the magnetic particles. The Fe3O4-GN composite is especially suitable for biodetection as a promising magnetic label since it combines two advantages of large fringing field and no aggregation. As a result, the concentration x dependence of voltage difference |ΔV| between detecting and reference sensors undergoes the relationship of |ΔV|=240.5lgx+515.2 with an ultralow detection limit of 10 ng/mL (very close to the calculated limit of 7 ng/mL) and a wide detection range of 4 orders.

关键词: giant magnetoresistance biosensors, magnetic label, Fe3O4-graphene composite, lowest detection limit

Abstract: A special Fe3O4 nanoparticles-graphene (Fe3O4-GN) composite as a magnetic label was employed for biodetection using giant magnetoresistance (GMR) sensors with a Wheatstone bridge. The Fe3O4-GN composite exhibits a strong ferromagnetic behavior with the saturation magnetization MS of approximately 48 emu/g, coercivity HC of 200 Oe, and remanence Mr of 8.3 emu/g, leading to a large magnetic fringing field. However, the Fe3O4 nanoparticles do not aggregate together, which can be attributed to the pinning and separating effects of graphene sheet to the magnetic particles. The Fe3O4-GN composite is especially suitable for biodetection as a promising magnetic label since it combines two advantages of large fringing field and no aggregation. As a result, the concentration x dependence of voltage difference |ΔV| between detecting and reference sensors undergoes the relationship of |ΔV|=240.5lgx+515.2 with an ultralow detection limit of 10 ng/mL (very close to the calculated limit of 7 ng/mL) and a wide detection range of 4 orders.

Key words: giant magnetoresistance biosensors, magnetic label, Fe3O4-graphene composite, lowest detection limit

中图分类号:  (Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing)

  • 07.07.Df
87.63.-d (Non-ionizing radiation equipment and techniques) 81.07.-b (Nanoscale materials and structures: fabrication and characterization) 81.05.-t (Specific materials: fabrication, treatment, testing, and analysis)