Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

doi:10.1088/1674-1056/23/10/104302

›› 2014, Vol. 23 ›› Issue (10): 104302-104302.doi: 10.1088/1674-1056/23/10/104302

• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇下一篇

Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

吴军^a, 范庭波^{b c}, 许迪^a, 章东^c

a The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;
b Jiangsu Provincial Institute for Medical Equipment Testing, Nanjing 210012, China;
c Institute of Acoustics, Key Laboratory of Modern Acoustics, Ministry of Education, Nanjing University, Nanjing 210093, China

收稿日期:2013-11-24 修回日期:2014-03-02 出版日期:2014-10-15 发布日期:2014-10-15
基金资助:
Project supported by the National Basic Research Program from Ministry of Science and Technology, China (Grant No. 2011CB707900), the National Natural Science Foundation of China (Grant Nos. 81271589, 81227004, 11174141, 11374155, 11612032, and 81301616), and the Natural Science Foundation of Jiangsu Province, China (Grant Nos. BE2011110 and BK20131017).

Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

Wu Jun (吴军)^a, Fan Ting-Bo (范庭波)^{b c}, Xu Di (许迪)^a, Zhang Dong (章东)^c

a The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;
b Jiangsu Provincial Institute for Medical Equipment Testing, Nanjing 210012, China;
c Institute of Acoustics, Key Laboratory of Modern Acoustics, Ministry of Education, Nanjing University, Nanjing 210093, China

Received:2013-11-24 Revised:2014-03-02 Online:2014-10-15 Published:2014-10-15
Contact: Xu Di,Zhang Dong E-mail:di_hsu@126.com;dzhang@nju.edu.cn
About author:43.25.+y; 43.80.+p
Supported by:
Project supported by the National Basic Research Program from Ministry of Science and Technology, China (Grant No. 2011CB707900), the National Natural Science Foundation of China (Grant Nos. 81271589, 81227004, 11174141, 11374155, 11612032, and 81301616), and the Natural Science Foundation of Jiangsu Province, China (Grant Nos. BE2011110 and BK20131017).

摘要/Abstract

摘要： Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate the dependence of the sub-harmonic generation on the overpressure with different excitation pressure amplitudes and pulse lengths. With 4-MHz ultrasound excitation at an applied acoustic pressure amplitude of 0.24 MPa, the measured sub-harmonic amplitude exhibits a decreasing change as overpressure increases; while non-monotonic change is observed for the applied acoustic pressures of 0.36 MPa and 0.48 MPa, and the peak position in the curve of the sub-harmonic response versus the overpressure shifts toward higher overpressure as the excitation pressure amplitude increases. Furthermore, the exciting pulse with long duration could lead to a better sensitivity of the sub-harmonic response to overpressure. The measured results are explained by the numerical simulations based on the Marmottant model. The numerical simulations qualitatively accord with the measured results. This work might provide a preliminary proof for the optimization of the noninvasive blood pressure measurement through using sub-harmonic generation from microbubbles.

关键词: microbubble, overpressure, sub-harmonic response, blood pressure measurement

Abstract: Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate the dependence of the sub-harmonic generation on the overpressure with different excitation pressure amplitudes and pulse lengths. With 4-MHz ultrasound excitation at an applied acoustic pressure amplitude of 0.24 MPa, the measured sub-harmonic amplitude exhibits a decreasing change as overpressure increases; while non-monotonic change is observed for the applied acoustic pressures of 0.36 MPa and 0.48 MPa, and the peak position in the curve of the sub-harmonic response versus the overpressure shifts toward higher overpressure as the excitation pressure amplitude increases. Furthermore, the exciting pulse with long duration could lead to a better sensitivity of the sub-harmonic response to overpressure. The measured results are explained by the numerical simulations based on the Marmottant model. The numerical simulations qualitatively accord with the measured results. This work might provide a preliminary proof for the optimization of the noninvasive blood pressure measurement through using sub-harmonic generation from microbubbles.

Key words: microbubble, overpressure, sub-harmonic response, blood pressure measurement

中图分类号: (Nonlinear acoustics)

43.25.+y

43.80.+p (Bioacoustics)

吴军, 范庭波, 许迪, 章东. Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles[J]. , 2014, 23(10): 104302-104302.

Wu Jun (吴军), Fan Ting-Bo (范庭波), Xu Di (许迪), Zhang Dong (章东). Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles[J]. Chin. Phys. B, 2014, 23(10): 104302-104302.

参考文献 0


[1]	Benisty J I 2002 Circulation 106 192 doi: 10.1161/01.CIR.0000042762.47822.FE

[1]	Raje A, Liaw S, Chary K V R and Davis B H 1995 Appl. Catal. A: Gen. 123 229 doi: 10.1016/0926-860X(94)00234-7

[2]	Zhang C B, Liu Z, Guo X S and Zhang D 2010 Chin. Phys. B 20 024301

[3]	Huang B, Zhang Y L, Zhang D and Gong X F 2010 Chin. Phys. B 19 054302

[4]	de Jong N, Corner R and Lance C T 1994 Ultrasonics 32 447 doi: 10.1016/0041-624X(94)90064-7

[5]	Shi W T and Forsberg F 2000 Ultrasound Med. Biol. 26 93 doi: 10.1016/S0301-5629(99)00117-9

[2]	Choi J G 2002 J. Ind. Eng. Chem. 8 1

[6]	Fairbank W M and Scully M O 1977 IEEE Trans. Biomed. Eng. 24 107

[3]	Li S, Lee J S, Hyeon T and Suslick K S 1999 Appl. Catal. A: Gen. 184 1 doi: 10.1016/S0926-860X(99)00044-7

[4]	Choi J G, Brenner J R, Colling C W, Demczyk B G, Dunning J L and Thompson L T 1992 Catal. Today 15 201 doi: 10.1016/0920-5861(92)80176-N

[7]	Bouakaz A, Frinking P J A, de Jong N and Bom N 1999 Ultrasound Med. Biol. 25 1407 doi: 10.1016/S0301-5629(99)00109-X

[5]	Trawczynski J 2000 Appl. Catal. A: Gen. 197 289 doi: 10.1016/S0926-860X(99)00490-1

[8]	Forsberg F, Liu J B, Shi W T, Furuse J, Shimizu M and Goldberg B B 2005 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52 581 doi: 10.1109/TUFFC.2005.1428040

[6]	Chuang J, Tu S and Chen M 1999 Thin Solid Films 346 299 doi: 10.1016/S0040-6090(98)01728-3

[7]	Hones P, Martin N, Regula M and Levy F 2003 J. Phys. D: Appl. Phys. 36 1023 doi: 10.1088/0022-3727/36/8/313

[9]	Shi W T, Forsberg F, Raichlen J S, Needleman L and Goldberg B B 1999 Ultrasound Med. Biol. 25 275 doi: 10.1016/S0301-5629(98)00163-X

[10]	Leodore L M, Forsberg F and Shi W T 2007 IEEE International Ultrasonics Symposium Proceedings, P5B-6

[8]	Solak N, Ustel F, Urgen M, Aydin S and Cakir A F 2003 Surf. Coat. Technol. 174 713

[11]	Frinking P J A, Gaud E, Brochot J and Arditi M 2010 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 57 1762 doi: 10.1109/TUFFC.2010.1614

[9]	Linker G, Smithey R and Meyer O 1984 J. Phys. F: Met. Phys. 14 L115

[10]	Inumaru K, Nishikawa T, Nakamura K and Yamanaka S 2008 Chem. Mater. 20 4756 doi: 10.1021/cm800820d

[12]	Andersen K S and Jensen J A 2009 J. Acoust. Soc. Am. 126 3350 doi: 10.1121/1.3242359

[11]	Ensinger W and Kiuchi M 1996 Surf. Coat. Technol. 84 425 doi: 10.1016/S0257-8972(95)02808-0

[13]	Katiyar A, Sarkar K and Forsberg F 2011 J. Acoust. Soc. Am. 129 2325 doi: 10.1121/1.3552884

[12]	Gajbhiye N S and Ningthoujam R S 2004 Phys. Status Solidi C 12 3449

[13]	Shen L and Wang N 2011 J. Nanomater. 2011 781935

[14]	Marmottant P, van der Meer S, Emmer M and Versluis M 2005 J. Acoust. Soc. Am. 118 3499 doi: 10.1121/1.2109427

[14]	Shen L H, Cui Q L, Zhang J, Li X F, Zhou Q and Zou G T 2005 Chin. Phys. Lett. 22 3192 doi: 10.1088/0256-307X/22/12/059

[15]	Zheng H R, Barker A and Shandas R 2006 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 53 639 doi: 10.1109/TUFFC.2006.1610573

[15]	Bogaerts A, Neyts E, Gijbels R and Mullen J V 2002 Spektrochim. Acta 57B 609

[16]	Tang M X, Loughran J, Stride E, Zhang D and Eckersley R J 2011 J. Acoust. Soc. Am. 129 EL76

[16]	Alsaran A and Celik A 2001 Mater. Charact. 47 207 doi: 10.1016/S1044-5803(01)00169-3

[17]	de Jong N, Emmer M, Chin C T, Bouskaz A, Mastik F, Lohse D and Versluis M 2007 Ultrasound Med. Biol. 37 653

[17]	Karakan M, Alsaran A and Celik A 2003 Mater. Charact. 49 241

[18]	Yu J F, Zhang D and Gong X F 2005 Chin. Phys. Lett. 22 892 doi: 10.1088/0256-307X/22/4/032

[18]	Ikhlaq U, Ahmad R, Saleem S, Shah M S, Umm-i-Kalsoom, Khan N and Khalid N 2012 Eur. Phys. J. Appl. Phys. 59 20801 doi: 10.1051/epjap/2012120173

[19]	Gong Y J, Zhang D and Gong X F 2005 Chin. Sci. Bull. 50 1975 doi: 10.1007/BF03322786

Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

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