Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

doi:10.1088/1674-1056/25/12/124308

中国物理B ›› 2016, Vol. 25 ›› Issue (12): 124308-124308.doi: 10.1088/1674-1056/25/12/124308

• SPECIAL TOPIC—Acoustics • 上一篇下一篇

Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

Xu-Dong Teng(滕旭东), Xia-Sheng Guo(郭霞生), Juan Tu(屠娟), Dong Zhang(章东)

Institute of Acoustics, Key Laboratory of Modern Acoustics(MOE), School of Physics, Nanjing University, Nanjing 210093, China

收稿日期:2016-05-11 修回日期:2016-07-10 出版日期:2016-12-05 发布日期:2016-12-05
通讯作者: Xia-Sheng Guo, Dong Zhang E-mail:guoxs@nju.edu.cn;dzhang@nju.edu.cn
基金资助:
Projects supported by the National Natural Science Foundation of China (Grant Nos. 81127901, 81227004, 11374155, 11274170, 11274176, 11474001, 11474161, 11474166, and 11674173), the National High-Technology Research and Development Program, China (Grant No. 2012AA022702), and Qing Lan Project of Jiangsu Province, China.

Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

Xu-Dong Teng(滕旭东), Xia-Sheng Guo(郭霞生), Juan Tu(屠娟), Dong Zhang(章东)

Institute of Acoustics, Key Laboratory of Modern Acoustics(MOE), School of Physics, Nanjing University, Nanjing 210093, China

Received:2016-05-11 Revised:2016-07-10 Online:2016-12-05 Published:2016-12-05
Contact: Xia-Sheng Guo, Dong Zhang E-mail:guoxs@nju.edu.cn;dzhang@nju.edu.cn
Supported by:
Projects supported by the National Natural Science Foundation of China (Grant Nos. 81127901, 81227004, 11374155, 11274170, 11274176, 11474001, 11474161, 11474166, and 11674173), the National High-Technology Research and Development Program, China (Grant No. 2012AA022702), and Qing Lan Project of Jiangsu Province, China.

摘要/Abstract

摘要：

Modelling and biomedical applications of ultrasound contrast agent (UCA) microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including (i) the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry; (ii) a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size; (iii) the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and (iv) the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures.

关键词: ultrasound contrast agents, microbubbles, nonlinear response, inertial cavitation, DNA transfection

Abstract:

Key words: ultrasound contrast agents, microbubbles, nonlinear response, inertial cavitation, DNA transfection

中图分类号: (Nonlinear acoustics)

43.25.+y

43.80.+p (Bioacoustics)

滕旭东, 郭霞生, 屠娟, 章东. Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications[J]. 中国物理B, 2016, 25(12): 124308-124308.

Xu-Dong Teng(滕旭东), Xia-Sheng Guo(郭霞生), Juan Tu(屠娟), Dong Zhang(章东). Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications[J]. Chin. Phys. B, 2016, 25(12): 124308-124308.

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Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

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