中国物理B ›› 2019, Vol. 28 ›› Issue (11): 114301-114301.doi: 10.1088/1674-1056/ab4d3f

• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇    下一篇

Dynamics of an ultrasound contrast agent microbubble near spherical boundary in ultrasound field

Ji-Wen Hu(胡继文), Lian-Mei Wang(王练妹), Sheng-You Qian(钱盛友), Wen-Yi Liu(刘文一), Ya-Tao Liu(刘亚涛), Wei-Rui Lei(雷卫瑞)   

  1. 1 School of Mathematics and Physics, University of South China, Hengyang 421001, China;
    2 School of Physics and Electronics, Hunan Normal University, Changsha 410081, China
  • 收稿日期:2019-08-27 修回日期:2019-09-29 出版日期:2019-11-05 发布日期:2019-11-05
  • 通讯作者: Sheng-You Qian E-mail:syqian@foxmail.com
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11774088 and 11474090), the Hunan-Provincial Natural Science Foundation of China (Grant No. 13JJ3076), and the Science Research Program of Education Department of Hunan Province of China (Grant No. 14A127).

Dynamics of an ultrasound contrast agent microbubble near spherical boundary in ultrasound field

Ji-Wen Hu(胡继文)1,2, Lian-Mei Wang(王练妹)1, Sheng-You Qian(钱盛友)2, Wen-Yi Liu(刘文一)1, Ya-Tao Liu(刘亚涛)1, Wei-Rui Lei(雷卫瑞)1   

  1. 1 School of Mathematics and Physics, University of South China, Hengyang 421001, China;
    2 School of Physics and Electronics, Hunan Normal University, Changsha 410081, China
  • Received:2019-08-27 Revised:2019-09-29 Online:2019-11-05 Published:2019-11-05
  • Contact: Sheng-You Qian E-mail:syqian@foxmail.com
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11774088 and 11474090), the Hunan-Provincial Natural Science Foundation of China (Grant No. 13JJ3076), and the Science Research Program of Education Department of Hunan Province of China (Grant No. 14A127).

摘要: The goal of this article is to establish the conditions of excitation where one has to deal with ultrasound contrast agent (UCA) microbubbles pulsating near biological tissues with spherical boundary in ultrasound field for targeted drug delivery and cavitation-enhanced thrombolysis, etc., and contributes to understanding of mechanisms at play in such an interaction. A modified model is presented for describing microbubble dynamics near a spherical boundary (including convex boundary and concave boundary) with an arbitrary-sized aperture angle. The novelty of the model is such that an oscillating microbubble is influenced by an additional pressure produced by the sound reflection from the boundary wall. It is found that the amplitude of microbubble oscillation is positively correlated to the curve radius of the wall and negatively correlated to the aperture angle of the wall and the sound reflection coefficient. Moreover, the natural frequency of the microbubble oscillation for such a compliable wall increases with the wall compliance, but decreases with the reduction of the wall size, indicating distinct increase of the natural frequency compared to a common rigid wall. The proposed model may allow obtaining accurate information on the radiation force and signals that may be used to advantage in related as drug delivery and contrast agent imaging.

关键词: ultrasound contrast agent (UCA) microbubble, spherical boundary, ultrasound, natural frequency

Abstract: The goal of this article is to establish the conditions of excitation where one has to deal with ultrasound contrast agent (UCA) microbubbles pulsating near biological tissues with spherical boundary in ultrasound field for targeted drug delivery and cavitation-enhanced thrombolysis, etc., and contributes to understanding of mechanisms at play in such an interaction. A modified model is presented for describing microbubble dynamics near a spherical boundary (including convex boundary and concave boundary) with an arbitrary-sized aperture angle. The novelty of the model is such that an oscillating microbubble is influenced by an additional pressure produced by the sound reflection from the boundary wall. It is found that the amplitude of microbubble oscillation is positively correlated to the curve radius of the wall and negatively correlated to the aperture angle of the wall and the sound reflection coefficient. Moreover, the natural frequency of the microbubble oscillation for such a compliable wall increases with the wall compliance, but decreases with the reduction of the wall size, indicating distinct increase of the natural frequency compared to a common rigid wall. The proposed model may allow obtaining accurate information on the radiation force and signals that may be used to advantage in related as drug delivery and contrast agent imaging.

Key words: ultrasound contrast agent (UCA) microbubble, spherical boundary, ultrasound, natural frequency

中图分类号:  (Nonlinear acoustics)

  • 43.25.+y
43.80.+p (Bioacoustics) 02.90.+p (Other topics in mathematical methods in physics)