Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

doi:10.1088/1674-1056/19/9/094302

中国物理B ›› 2010, Vol. 19 ›› Issue (9): 94302-094302.doi: 10.1088/1674-1056/19/9/094302

Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

邱媛媛¹, 黄蓓¹, 章东¹, 龚秀芬¹, 马青玉²

(1)Key Laboratory of Modern Acoustics, Ministry of Education, Institute of Acoustics, Nanjing University, Nanjing 210093, China; (2)School of Physics and Technology, Nanjing Normal University, Nanjing 210097, China

收稿日期:2009-11-24 修回日期:2010-03-28 出版日期:2010-09-15 发布日期:2010-09-15
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 10974098 and 10774071), the Natural Science Foundation of Jiangsu Province, China (Grant No. BK2009407), the Doctoral Foundation of Ministry of Education of China (Grant No.

Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

Ma Qing-Yu(马青玉)^a), Qiu Yuan-Yuan(邱媛媛)^b), Huang Bei(黄蓓)^b), Zhang Dong(章东)^b)†, and Gong Xiu-Fen(龚秀芬)^b)

^a School of Physics and Technology, Nanjing Normal University, Nanjing 210097, China; ^b Key Laboratory of Modern Acoustics, Ministry of Education, Institute of Acoustics, Nanjing University, Nanjing 210093, China

Received:2009-11-24 Revised:2010-03-28 Online:2010-09-15 Published:2010-09-15
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 10974098 and 10774071), the Natural Science Foundation of Jiangsu Province, China (Grant No. BK2009407), the Doctoral Foundation of Ministry of Education of China (Grant No. 20093207120003), and the National Basic Research Program of China (Grant No. 2010CB732600).

摘要/Abstract

摘要： The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast agents infusion, the harmonic components scattered from the microbubbles, including DF, can be generated due to the nonlinear vibration. A theoretical study on the DF generation from microbubbles under the dual-frequency excitation is proposed in formula based on the solution of the RPNNP equation. The optimisation of the DF generation is discussed associated with the applied acoustic pressure, frequency, and the microbubble size. Experiments are performed to validate the theoretical predictions by using a dual-frequency signal to excite microbubbles. Both the numerical and experimental results demonstrate that the optimised DF ultrasound can be achieved as the difference frequency is close to the resonance frequency of the microbubble and improve the contrast-to-tissue ratio in imaging.

Abstract: The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast agents infusion, the harmonic components scattered from the microbubbles, including DF, can be generated due to the nonlinear vibration. A theoretical study on the DF generation from microbubbles under the dual-frequency excitation is proposed in formula based on the solution of the RPNNP equation. The optimisation of the DF generation is discussed associated with the applied acoustic pressure, frequency, and the microbubble size. Experiments are performed to validate the theoretical predictions by using a dual-frequency signal to excite microbubbles. Both the numerical and experimental results demonstrate that the optimised DF ultrasound can be achieved as the difference frequency is close to the resonance frequency of the microbubble and improve the contrast-to-tissue ratio in imaging.

Key words: difference-frequency, microbubble, dual-frequency excitation, parametric effect

中图分类号:

4335

马青玉, 邱媛媛, 黄蓓, 章东, 龚秀芬. Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation[J]. 中国物理B, 2010, 19(9): 94302-094302.

Ma Qing-Yu(马青玉), Qiu Yuan-Yuan(邱媛媛), Huang Bei(黄蓓), Zhang Dong(章东), and Gong Xiu-Fen(龚秀芬). Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation[J]. Chin. Phys. B, 2010, 19(9): 94302-094302.

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Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

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