Spiking patterns of a hippocampus model in electric fields

doi:10.1088/1674-1056/20/12/128704

中国物理B ›› 2011, Vol. 20 ›› Issue (12): 128704-128704.doi: 10.1088/1674-1056/20/12/128704

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇下一篇

Spiking patterns of a hippocampus model in electric fields

门聪¹, 王江¹, 秦迎梅¹, 魏熙乐¹, 邓斌¹, 车艳秋²

(1)School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China; (2)Tianjin Key Laboratory of Information Sensing and Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China

收稿日期:2011-06-08 修回日期:2011-07-06 出版日期:2011-12-15 发布日期:2011-12-15
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 61072012, 60901035, and 50907044).

Spiking patterns of a hippocampus model in electric fields

Men Cong(门聪)^a), Wang Jiang(王江) ^a)^†, Qin Ying-Mei(秦迎梅)^a), Wei Xi-Le(魏熙乐)^a), Che Yan-Qiu(车艳秋)^b), and Deng Bin(邓斌)^a)

^a School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China; ^b Tianjin Key Laboratory of Information Sensing and Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China

Received:2011-06-08 Revised:2011-07-06 Online:2011-12-15 Published:2011-12-15
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 61072012, 60901035, and 50907044).

摘要/Abstract

摘要： We develop a model of CA3 neurons embedded in a resistive array to mimic the effects of electric fields from a new perspective. Effects of DC and sinusoidal electric fields on firing patterns in CA3 neurons are investigated in this study. The firing patterns can be switched from no firing pattern to burst or from burst to fast periodic firing pattern with the increase of DC electric field intensity. It is also found that the firing activities are sensitive to the frequency and amplitude of the sinusoidal electric field. Different phase-locking states and chaotic firing regions are observed in the parameter space of frequency and amplitude. These findings are qualitatively in accordance with the results of relevant experimental and numerical studies. It is implied that the external or endogenous electric field can modulate the neural code in the brain. Furthermore, it is helpful to develop control strategies based on electric fields to control neural diseases such as epilepsy.

Abstract: We develop a model of CA3 neurons embedded in a resistive array to mimic the effects of electric fields from a new perspective. Effects of DC and sinusoidal electric fields on firing patterns in CA3 neurons are investigated in this study. The firing patterns can be switched from no firing pattern to burst or from burst to fast periodic firing pattern with the increase of DC electric field intensity. It is also found that the firing activities are sensitive to the frequency and amplitude of the sinusoidal electric field. Different phase-locking states and chaotic firing regions are observed in the parameter space of frequency and amplitude. These findings are qualitatively in accordance with the results of relevant experimental and numerical studies. It is implied that the external or endogenous electric field can modulate the neural code in the brain. Furthermore, it is helpful to develop control strategies based on electric fields to control neural diseases such as epilepsy.

Key words: electric field, Pinsky-Rinzel neuron, phase locking, firing pattern

中图分类号: (Neuroscience)

87.19.L-

05.45.-a (Nonlinear dynamics and chaos)

门聪, 王江, 秦迎梅, 魏熙乐, 车艳秋, 邓斌. Spiking patterns of a hippocampus model in electric fields[J]. 中国物理B, 2011, 20(12): 128704-128704.

Men Cong(门聪), Wang Jiang(王江) , Qin Ying-Mei(秦迎梅), Wei Xi-Le(魏熙乐), Che Yan-Qiu(车艳秋), and Deng Bin(邓斌) . Spiking patterns of a hippocampus model in electric fields[J]. Chin. Phys. B, 2011, 20(12): 128704-128704.

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Spiking patterns of a hippocampus model in electric fields

Spiking patterns of a hippocampus model in electric fields

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