Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication

doi:10.1088/1674-1056/ac6dbc

中国物理B ›› 2023, Vol. 32 ›› Issue (2): 20502-020502.doi: 10.1088/1674-1056/ac6dbc

Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication

Zhixuan Yuan(袁治轩)¹, Mengmeng Du(独盟盟)², Yangyang Yu(于羊羊)¹, and Ying Wu(吴莹)^1,†

1 State Key Laboratory for Strength and Vibration of Mechanical Structures, Shaanxi Engineering Laboratory for Vibration Control of Aerospace Structures, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China;
2 School of Mathematics and Data Science, Shaanxi University of Science and Technology, Xi'an 710000, China

收稿日期:2022-02-05 修回日期:2022-04-10 接受日期:2022-05-07 出版日期:2023-01-10 发布日期:2023-01-18
通讯作者: Ying Wu E-mail:wying36@xjtu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 12132012 and 11972275) and the National Science Foundation for Young Scientists of China (Grant No. 12102240).

Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication

Zhixuan Yuan(袁治轩)¹, Mengmeng Du(独盟盟)², Yangyang Yu(于羊羊)¹, and Ying Wu(吴莹)^1,†

1 State Key Laboratory for Strength and Vibration of Mechanical Structures, Shaanxi Engineering Laboratory for Vibration Control of Aerospace Structures, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China;
2 School of Mathematics and Data Science, Shaanxi University of Science and Technology, Xi'an 710000, China

Received:2022-02-05 Revised:2022-04-10 Accepted:2022-05-07 Online:2023-01-10 Published:2023-01-18
Contact: Ying Wu E-mail:wying36@xjtu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 12132012 and 11972275) and the National Science Foundation for Young Scientists of China (Grant No. 12102240).

摘要/Abstract

摘要： Experimental records in the cerebral cortex indicate that ammonia injection can lead to seizures. Considering that astrocytes play a vital role in mediating the uptake and absorption of ammonium ions in the extracellular space of the cortical circuit, we constructed a new astrocyte neuron coupling model, which is composed of a neuron and its astrocytes connected through the extracellular space, taking into account of the influence of extracellular ammonium ions. The numerical results verified the previous experimental observation that obtained epileptic firing modes of neurons and postsynaptic GABA reversal potential depolarization triggered by ammonia injection. In addition, we also determined the concentration-response relationship between the ammonium ion concentration and the time of entering epilepsy and predicted the threshold of the ammonium ion concentration for the onset of epilepsy.

关键词: ammonia, neuron, astrocyte, epilepsy

Abstract: Experimental records in the cerebral cortex indicate that ammonia injection can lead to seizures. Considering that astrocytes play a vital role in mediating the uptake and absorption of ammonium ions in the extracellular space of the cortical circuit, we constructed a new astrocyte neuron coupling model, which is composed of a neuron and its astrocytes connected through the extracellular space, taking into account of the influence of extracellular ammonium ions. The numerical results verified the previous experimental observation that obtained epileptic firing modes of neurons and postsynaptic GABA reversal potential depolarization triggered by ammonia injection. In addition, we also determined the concentration-response relationship between the ammonium ion concentration and the time of entering epilepsy and predicted the threshold of the ammonium ion concentration for the onset of epilepsy.

Key words: ammonia, neuron, astrocyte, epilepsy

中图分类号: (Nonlinear dynamics and chaos)

05.45.-a

64.70.qj (Dynamics and criticality) 87.19.L- (Neuroscience) 87.19.lk (Glia)

Zhixuan Yuan(袁治轩), Mengmeng Du(独盟盟), Yangyang Yu(于羊羊), and Ying Wu(吴莹). Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication[J]. 中国物理B, 2023, 32(2): 20502-020502.

Zhixuan Yuan(袁治轩), Mengmeng Du(独盟盟), Yangyang Yu(于羊羊), and Ying Wu(吴莹). Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication[J]. Chin. Phys. B, 2023, 32(2): 20502-020502.

参考文献

[1] Ip Y K and Chew S F 2010 Front. Physiol. 1 134
[2] Cagnon L and Braissant O 2007 Brain Res. Rev. 56 183
[3] Marcaggi P, Jeanne M and Coles J A 2004 Eur. J. Neurosci. 19 966
[4] Cooper A J 2011 Neurochem. Int. 59 456
[5] Waniewski R A 1992 J. Neurochem. 58 167
[6] Martinez H A, Bell K P and Norenberg M D 1977 Science. 195 1356
[7] Norenberg M D and Martinez H A 1979 Brain Res. 161 303
[8] Weil M H 1962 Neurochemistry. 321
[9] Van den Berg C J 1969 Handbook of Neurochemistry. 3 355
[10] Thrane V R, Thrane A S, Wang F, et al. 2013 Nature Med. 19 1643
[11] Kucheryavykh Y V, Kucheryavykh L Y, Nichols C G, et al. 2007 Glia. 55 274
[12] Butt A M and Kalsi A 2006 J. Cell Mol. Med. 10 33
[13] Heuser K, Eid T, Lauritzen F, et al. 2012 J. Neuropathol Exp. Neurol. 71 814
[14] Tong X, Ao Y, Faas G C, et al. 2014 Nature Neuroscience. 17 694
[15] Cressman J R, Ullah G, Ziburkus J, et al. 2009 J. Comput. Neurosci. 26 159
[16] David Y, Cacheaux L P, Ivens S, et al. 2009 J. Neurosci Off. J. Soc. Neurosci. 29 10588
[17] Wei Y N, Ullah G and Schiff S J 2014 J. Neurosci Off. J. Soc. Neurosci. 34 11733
[18] Wei Y N, Ullah G, Ingram J, et al. 2014 J. Neurophysiol. 112 213
[19] Kager H, Wadman W J and Somjen G G 2000 J. Neurophysiol. 84 495
[20] Du M M, Li J J, Yuan Z X, et al. 2020 Chin. Phys. B. 29 038701
[21] Østby I, Øyehaug L, Einevoll G T, et al. 2009 PLoS Comput. Biol. 5 e1000272
[22] Øyehaug L, Østby I, Lloyd C M, et al. 2012 J. Comput. Neurosci. 32 147
[23] Witthoft A, Filosa J A and Karniadakis G E 2013 Biophys J. 105 2046
[24] Sibille J, Dao D K, Holcman D, et al. 2015 PLoS Comput. Biol. 11 e1004137
[25] Du M M, Li J J, Liang C, et al. 2018 Plos Comput. Biology. 14 e1005877
[26] Basile A S 2002 Neurochem. Internat. 41 115
[27] Traynelis S F and Dingledine R 1988 J. Neurophysiol. 59 259
[28] Ingram J M, Zhang C, Xu J, et al. 2013 J. Neurosci Methods. 214 45
[29] Ziburkus J, Cressman J R, Barreto E, et al. 2006 J. Neurophysiol. 95 3948
[30] Sivilotti L and Nistri A 1991 Prog. Neurobiology. 36 35
[31] Knowles W D, Schneiderman J H, Wheal H V, et al. 1984 Cellular Molecul. Neurobiology. 4 207
[32] Newberry N R and Nicoll R A 1984 J. Physiology. 348 239
[33] Iles J F and Jack J J 1983 Brain. 103 555
[34] Cooper A J and Plum F 1987 Physiological Rev. 67 440
[35] Raichle M E and Larson K B 1981 Circ. Res. 48 913
[36] Dombro R S, Hutson D G and Norenberg M D 1993 Mol. Chem. Neuropathol. 19 259
[37] Norenberg M D 1987 Neurochem. Pathol. 6 13
[38] Subbalakshmi G Y and Murthy C R 1983 Neurochem. Int. 5 593
[39] Plum F and Hindfelt B 1976 Handbook of Clinical Neurology 27 349
[40] Crossley I R, Wardle E N and Williams R 1983 Clin. Sci. 64 247
[41] Lux H D and Neher E 1970 Exp. Brain Res. 11 431
[42] Takahashi K, Kameda H, Kataoka M, et al. 1993 Neurosci. Lett. 151 51

Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication

Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication

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