Simulation of the physical process of neural electromagnetic signal generation based on a simple but functional bionic Na+ channel

doi:10.1088/1674-1056/ac3cac

中国物理B ›› 2022, Vol. 31 ›› Issue (6): 68701-068701.doi: 10.1088/1674-1056/ac3cac

Simulation of the physical process of neural electromagnetic signal generation based on a simple but functional bionic Na⁺ channel

Fan Wang(王帆)^1,†, Jingjing Xu(徐晶晶)^1,2,†,‡, Yanbin Ge(葛彦斌)¹, Shengyong Xu(许胜勇)³, Yanjun Fu(付琰军)⁴, Caiyu Shi(石蔡语)¹, and Jianming Xue(薛建明)^4,§

1 Institute of Microelectronics, Shandong University, Jinan 250102, China;
2 Shenzhen Research Institute of Shandong University, Shenzhen 518057, China;
3 Key Laboratory for the Physics&Chemistry of Nanodevices, and Department of Electronics, Peking University, Beijing 100871, China;
4 School of Physics, Peking University, Beijing 100871, China

收稿日期:2021-08-17 修回日期:2021-10-18 接受日期:2021-11-24 出版日期:2022-05-17 发布日期:2022-05-17
通讯作者: Jingjing Xu, Jianming Xue E-mail:xujj@sdu.edu.cn;jmxue@pku.edu.cn
基金资助:
The authors are grateful to Prof. Mingzhi Li for valuable discussions. Project supported by the National Key Research and Development Program of China (Grant No. 2017YFA0701302), the Natural Science Foundation of Shandong Province, China (Grant No. ZR2020QA063), and Guangdong Basic and Applied Basic Research Foundation, China (Grant No. 2020A1515111180).

Simulation of the physical process of neural electromagnetic signal generation based on a simple but functional bionic Na⁺ channel

Fan Wang(王帆)^1,†, Jingjing Xu(徐晶晶)^1,2,†,‡, Yanbin Ge(葛彦斌)¹, Shengyong Xu(许胜勇)³, Yanjun Fu(付琰军)⁴, Caiyu Shi(石蔡语)¹, and Jianming Xue(薛建明)^4,§

1 Institute of Microelectronics, Shandong University, Jinan 250102, China;
2 Shenzhen Research Institute of Shandong University, Shenzhen 518057, China;
3 Key Laboratory for the Physics&Chemistry of Nanodevices, and Department of Electronics, Peking University, Beijing 100871, China;
4 School of Physics, Peking University, Beijing 100871, China

Received:2021-08-17 Revised:2021-10-18 Accepted:2021-11-24 Online:2022-05-17 Published:2022-05-17
Contact: Jingjing Xu, Jianming Xue E-mail:xujj@sdu.edu.cn;jmxue@pku.edu.cn
Supported by:
The authors are grateful to Prof. Mingzhi Li for valuable discussions. Project supported by the National Key Research and Development Program of China (Grant No. 2017YFA0701302), the Natural Science Foundation of Shandong Province, China (Grant No. ZR2020QA063), and Guangdong Basic and Applied Basic Research Foundation, China (Grant No. 2020A1515111180).

摘要/Abstract

摘要： The physical processes occurring at open Na⁺ channels in neural fibers are essential for the understanding of the nature of neural signals and the mechanism by which the signals are generated and transmitted along nerves. However, there is a less generally accepted description of these physical processes. We studied changes in the transmembrane ionic flux and the resulting two types of electromagnetic signals by simulating the Na⁺ transport across a bionic nanochannel model simplified from voltage-gated Na⁺ channels. The results show that the Na⁺ flux can reach a steady state in approximately 10 ns due to the dynamic equilibrium of the Na⁺ ion concentration difference between both sides of the membrane. After characterizing the spectrum and transmission of these two electromagnetic signals, the low-frequency transmembrane electric field is regarded as the physical quantity transmitting in the waveguide-like lipid dielectric layer and triggering the neighboring voltage-gated channels. Factors influencing the Na⁺ flux transport are also studied. The impact of the Na⁺ concentration gradient is found to be higher than that of the initial transmembrane potential on the Na⁺ transport rate, and introducing the surface-negative charge in the upper third channel could increase the transmembrane Na⁺ current. This work can be further studied by improving the simulation model; however, the current work helps to better understand the electrical functions of voltage-gated ion channels in neural systems.

关键词: neural signals, sodium-ion channel, transmembrane current, electromagnetic field

Abstract: The physical processes occurring at open Na⁺ channels in neural fibers are essential for the understanding of the nature of neural signals and the mechanism by which the signals are generated and transmitted along nerves. However, there is a less generally accepted description of these physical processes. We studied changes in the transmembrane ionic flux and the resulting two types of electromagnetic signals by simulating the Na⁺ transport across a bionic nanochannel model simplified from voltage-gated Na⁺ channels. The results show that the Na⁺ flux can reach a steady state in approximately 10 ns due to the dynamic equilibrium of the Na⁺ ion concentration difference between both sides of the membrane. After characterizing the spectrum and transmission of these two electromagnetic signals, the low-frequency transmembrane electric field is regarded as the physical quantity transmitting in the waveguide-like lipid dielectric layer and triggering the neighboring voltage-gated channels. Factors influencing the Na⁺ flux transport are also studied. The impact of the Na⁺ concentration gradient is found to be higher than that of the initial transmembrane potential on the Na⁺ transport rate, and introducing the surface-negative charge in the upper third channel could increase the transmembrane Na⁺ current. This work can be further studied by improving the simulation model; however, the current work helps to better understand the electrical functions of voltage-gated ion channels in neural systems.

Key words: neural signals, sodium-ion channel, transmembrane current, electromagnetic field

中图分类号: (Neuroscience)

87.19.L-

87.16.Vy (Ion channels) 87.19.rp (Impulse propagation) 87.19.lq (Neuronal wave propagation)

Fan Wang(王帆), Jingjing Xu(徐晶晶), Yanbin Ge(葛彦斌), Shengyong Xu(许胜勇),Yanjun Fu(付琰军), Caiyu Shi(石蔡语), and Jianming Xue(薛建明). Simulation of the physical process of neural electromagnetic signal generation based on a simple but functional bionic Na⁺ channel[J]. 中国物理B, 2022, 31(6): 68701-068701.

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Simulation of the physical process of neural electromagnetic signal generation based on a simple but functional bionic Na⁺ channel

Simulation of the physical process of neural electromagnetic signal generation based on a simple but functional bionic Na⁺ channel

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