中国物理B ›› 2011, Vol. 20 ›› Issue (12): 128704-128704.doi: 10.1088/1674-1056/20/12/128704
• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇 下一篇
门聪1, 王江1, 秦迎梅1, 魏熙乐1, 邓斌1, 车艳秋2
Men Cong(门聪)a), Wang Jiang(王江) a)†, Qin Ying-Mei(秦迎梅)a), Wei Xi-Le(魏熙乐)a), Che Yan-Qiu(车艳秋)b), and Deng Bin(邓斌)a)
摘要: We develop a model of CA3 neurons embedded in a resistive array to mimic the effects of electric fields from a new perspective. Effects of DC and sinusoidal electric fields on firing patterns in CA3 neurons are investigated in this study. The firing patterns can be switched from no firing pattern to burst or from burst to fast periodic firing pattern with the increase of DC electric field intensity. It is also found that the firing activities are sensitive to the frequency and amplitude of the sinusoidal electric field. Different phase-locking states and chaotic firing regions are observed in the parameter space of frequency and amplitude. These findings are qualitatively in accordance with the results of relevant experimental and numerical studies. It is implied that the external or endogenous electric field can modulate the neural code in the brain. Furthermore, it is helpful to develop control strategies based on electric fields to control neural diseases such as epilepsy.
中图分类号: (Neuroscience)