Self-assembled superparamagnetic nanoparticles as MRI contrast agents–A review

doi:10.1088/1674-1056/24/12/127506

中国物理B ›› 2015, Vol. 24 ›› Issue (12): 127506-127506.doi: 10.1088/1674-1056/24/12/127506

所属专题： TOPICAL REVIEW — Magnetism, magnetic materials, and interdisciplinary research

• SPECIAL TOPIC --- Non-equilibrium phenomena in soft matters • 上一篇下一篇

Self-assembled superparamagnetic nanoparticles as MRI contrast agents–A review

苏红莹^a, 吴昌强^b, 李丹阳^c, 艾华^b

a Department of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, China;
b National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China;
c School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK

收稿日期:2015-07-13 修回日期:2015-08-17 出版日期:2015-12-05 发布日期:2015-12-05
通讯作者: Su Hong-Ying, Wu Chang-Qiang, Ai Hua E-mail:yukisusu@aliyun.com;huaai@scu.edu.cn
基金资助:
Project supported by the National Key Basic Research Program of China (Grant No. 2013CB933903), the National Natural Science Foundation of China (Grant Nos. 20974065, 51173117, and 50830107), and the Scientific Research Start-up Fund of Kunming University of Science and Technology (Grant No. KKSY201305089). These authors contributed equally to this work.

Self-assembled superparamagnetic nanoparticles as MRI contrast agents–A review

Su Hong-Ying (苏红莹)^a, Wu Chang-Qiang (吴昌强)^b, Li Dan-Yang (李丹阳)^c, Ai Hua (艾华)^b

a Department of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, China;
b National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China;
c School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK

Received:2015-07-13 Revised:2015-08-17 Online:2015-12-05 Published:2015-12-05
Contact: Su Hong-Ying, Wu Chang-Qiang, Ai Hua E-mail:yukisusu@aliyun.com;huaai@scu.edu.cn
Supported by:
Project supported by the National Key Basic Research Program of China (Grant No. 2013CB933903), the National Natural Science Foundation of China (Grant Nos. 20974065, 51173117, and 50830107), and the Scientific Research Start-up Fund of Kunming University of Science and Technology (Grant No. KKSY201305089). These authors contributed equally to this work.

摘要/Abstract

摘要：

Recent progress of the preparation and applications of superparamagnetic iron oxide (SPIO) clusters as magnetic resonance imaging (MRI) probes is reviewed with regard to their applications in labeling and tracking cells in vivo, in diagnosis of cardiovascular diseases and tumors, and in drug delivery systems. Magnetic nanoparticles (NPs), especially SPIO nanoparticles, have long been used as MRI contrast agents and as an advantageous nanoplatform for drug delivery, taking advantage of their unique magnetic properties and ability to function at the molecular and cellular levels. Due to advances in nanotechnology, various means to control SPIO NPs' size, composition, magnetization and relaxivity have been developed, as well as ways to usefully modify their surface. Recently, self-assembly of SPIO NP clusters in particulate carriers–such as polymeric micelles, vesicles, liposomes, and layer-by-layer (LbL) capsules–have been widely studied for application as ultrasensitive MRI probes, owing to their remarkably high spin-spin (T₂) relaxivity and convenience for further functionalization.

关键词: superparamagnetic iron nanoparticles, magnetic resonance imaging, contrast agent, self-assembly

Abstract:

Key words: superparamagnetic iron nanoparticles, magnetic resonance imaging, contrast agent, self-assembly

中图分类号: (Magnetic properties of nanostructures)

75.75.-c

81.16.Dn (Self-assembly) 87.61.-c (Magnetic resonance imaging) 87.85.J- (Biomaterials)

苏红莹, 吴昌强, 李丹阳, 艾华. Self-assembled superparamagnetic nanoparticles as MRI contrast agents–A review[J]. 中国物理B, 2015, 24(12): 127506-127506.

Su Hong-Ying (苏红莹), Wu Chang-Qiang (吴昌强), Li Dan-Yang (李丹阳), Ai Hua (艾华). Self-assembled superparamagnetic nanoparticles as MRI contrast agents–A review[J]. Chin. Phys. B, 2015, 24(12): 127506-127506.

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Self-assembled superparamagnetic nanoparticles as MRI contrast agents–A review

Self-assembled superparamagnetic nanoparticles as MRI contrast agents–A review

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