中国物理B ›› 2016, Vol. 25 ›› Issue (1): 16401-016401.doi: 10.1088/1674-1056/25/1/016401

所属专题: TOPICAL REVIEW — 8th IUPAP International Conference on Biological Physics

• TOPICAL REVIEW—8th IUPAP International Conference on Biological Physics • 上一篇    下一篇

Uncovering the underlying physical mechanisms of biological systems via quantification of landscape and flux

Li Xu(徐丽), Xiakun Chu(楚夏昆), Zhiqiang Yan(晏致强), Xiliang Zheng(郑喜亮), Kun Zhang(张坤), Feng Zhang(张锋), Han Yan(闫晗), Wei Wu(吴畏), Jin Wang(汪劲)   

  1. 1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
    2. Department of Chemistry and Physics, Stony Brook University, Stony Brook, NY 11794-3400, USA
  • 收稿日期:2015-05-08 修回日期:2015-10-08 出版日期:2016-01-05 发布日期:2016-01-05
  • 通讯作者: Li Xu, Jin Wang E-mail:jin.wang.1@stonybrook.edu
  • 基金资助:

    Project supported by the Natural Science Foundation of China (Grant Nos. 21190040, 11174105, 91225114, 91430217, and 11305176) and Jilin Province Youth Foundation, China (Grant No. 20150520082JH).

Uncovering the underlying physical mechanisms of biological systems via quantification of landscape and flux

Li Xu(徐丽)1, Xiakun Chu(楚夏昆)1, Zhiqiang Yan(晏致强)1, Xiliang Zheng(郑喜亮)1, Kun Zhang(张坤)1, Feng Zhang(张锋)1, Han Yan(闫晗)1, Wei Wu(吴畏)1, Jin Wang(汪劲)1,2   

  1. 1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
    2. Department of Chemistry and Physics, Stony Brook University, Stony Brook, NY 11794-3400, USA
  • Received:2015-05-08 Revised:2015-10-08 Online:2016-01-05 Published:2016-01-05
  • Contact: Li Xu, Jin Wang E-mail:jin.wang.1@stonybrook.edu
  • Supported by:

    Project supported by the Natural Science Foundation of China (Grant Nos. 21190040, 11174105, 91225114, 91430217, and 11305176) and Jilin Province Youth Foundation, China (Grant No. 20150520082JH).

摘要:

In this review, we explore the physical mechanisms of biological processes such as protein folding and recognition, ligand binding, and systems biology, including cell cycle, stem cell, cancer, evolution, ecology, and neural networks. Our approach is based on the landscape and flux theory for nonequilibrium dynamical systems. This theory provides a unifying principle and foundation for investigating the underlying mechanisms and physical quantification of biological systems.

关键词: landscape, flux

Abstract:

In this review, we explore the physical mechanisms of biological processes such as protein folding and recognition, ligand binding, and systems biology, including cell cycle, stem cell, cancer, evolution, ecology, and neural networks. Our approach is based on the landscape and flux theory for nonequilibrium dynamical systems. This theory provides a unifying principle and foundation for investigating the underlying mechanisms and physical quantification of biological systems.

Key words: landscape, flux

中图分类号:  (Networks)

  • 64.60.aq
87.18.Vf (Systems biology) 87.19.ll (Models of single neurons and networks) 87.23.-n (Ecology and evolution)