中国物理B ›› 2009, Vol. 18 ›› Issue (11): 4932-4937.doi: 10.1088/1674-1056/18/11/052

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Influence of the abdominal wall on the nonlinear propagation of focused therapeutic ultrasound

范庭波1, 章东1, 龚秀芬1, 刘振波2   

  1. (1)Institute of Acoustics, Key Lab of Modern Acoustics, Nanjing University, Nanjing 210093, China; (2)Institute of Acoustics, Key Lab of Modern Acoustics, Nanjing University, Nanjing 210093, China;Nanjing Normal University, Nanjing 210097, China
  • 收稿日期:2009-04-15 修回日期:2009-06-07 出版日期:2009-11-20 发布日期:2009-11-20
  • 基金资助:
    Project supported by the Program for New Century Excellent Talents in University of China (Grant No 06-0450), the National Natural Science Foundation of China (Grant No 10774071) and the Natural Science Foundation of Jiangsu Province, China (Grant No BK2007518).

Influence of the abdominal wall on the nonlinear propagation of focused therapeutic ultrasound

Liu Zhen-Bo(刘振波)a)b),Fan Ting-Bo(范庭波) a), Zhang Dong(章东)a)†, and Gong Xiu-Fen(龚秀芬)a)   

  1. a Institute of Acoustics, Key Lab of Modern Acoustics, Nanjing University, Nanjing 210093, China; b Nanjing Normal University, Nanjing 210097, China
  • Received:2009-04-15 Revised:2009-06-07 Online:2009-11-20 Published:2009-11-20
  • Supported by:
    Project supported by the Program for New Century Excellent Talents in University of China (Grant No 06-0450), the National Natural Science Foundation of China (Grant No 10774071) and the Natural Science Foundation of Jiangsu Province, China (Grant No BK2007518).

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摘要： This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogeneous medium and a phase aberration screen. Variations of acoustic parameters such as peak positive pressure, peak negative pressure, and acoustic intensity are discussed with respect to the phase screen statistics of human abdominal walls. Results indicate that the abdominal wall can result in energy loss of the sound in the focal plane. For a typical human abdominal wall with correlation length of 7.9~mm and variance of 0.36, the peak acoustic intensity radiated from a 1~MHz transmitter with a radius of 30~mm can be reduced by about 14% at the focal plane.

Abstract: This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogeneous medium and a phase aberration screen. Variations of acoustic parameters such as peak positive pressure, peak negative pressure, and acoustic intensity are discussed with respect to the phase screen statistics of human abdominal walls. Results indicate that the abdominal wall can result in energy loss of the sound in the focal plane. For a typical human abdominal wall with correlation length of 7.9 mm and variance of 0.36, the peak acoustic intensity radiated from a 1 MHz transmitter with a radius of 30 mm can be reduced by about 14% at the focal plane.

Key words: phase aberration , focused therapeutic ultrasound , abdominal wall

中图分类号:  (Biological effects of acoustic and ultrasonic energy)

  • 87.50.Y-
87.50.yt (Therapeutic applications) 87.85.Lf (Tissue engineering)