Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

doi:10.1088/1674-1056/27/7/078701

中国物理B ›› 2018, Vol. 27 ›› Issue (7): 78701-078701.doi: 10.1088/1674-1056/27/7/078701

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇下一篇

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

Shi-Hui Chang(常诗卉), Rui Cao(曹睿), Ya-Bin Zhang(张亚斌), Pei-Guo Wang(王佩国), Shi-Jing Wu(吴世敬), Yu-Han Qian(钱宇晗), Xi-Qi Jian(菅喜岐)

1 School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China;
2 College of Mechanical Engineering, Tianjin University of Science & Technology, Tianjin 300222, China;
3 Union Stem Cell & Gene Engineering Co., Ltd., Tianjin 300384, China;
4 Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China

收稿日期:2018-02-02 修回日期:2018-05-01 出版日期:2018-07-05 发布日期:2018-07-05
通讯作者: Xi-Qi Jian E-mail:jianxiqi@tmu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

Shi-Hui Chang(常诗卉)¹, Rui Cao(曹睿)², Ya-Bin Zhang(张亚斌)^1,3, Pei-Guo Wang(王佩国)⁴, Shi-Jing Wu(吴世敬)¹, Yu-Han Qian(钱宇晗)¹, Xi-Qi Jian(菅喜岐)¹

1 School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China;
2 College of Mechanical Engineering, Tianjin University of Science & Technology, Tianjin 300222, China;
3 Union Stem Cell & Gene Engineering Co., Ltd., Tianjin 300384, China;
4 Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China

Received:2018-02-02 Revised:2018-05-01 Online:2018-07-05 Published:2018-07-05
Contact: Xi-Qi Jian E-mail:jianxiqi@tmu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).

摘要/Abstract

摘要： Recently, the phase compensation technique has allowed the ultrasound to propagate through the skull and focus into the brain. However, the temperature evolution during treatment is hard to control to achieve effective treatment and avoid over-high temperature. Proposed in this paper is a method to modulate the temperature distribution in the focal region. It superimposes two signals which focus on two preset different targets with a certain distance. Then the temperature distribution is modulated by changing triggering time delay and amplitudes of the two signals. The simulation model is established based on an 82-element transducer and computed tomography (CT) data of a volunteer's head. A finite-difference time-domain (FDTD) method is used to calculate the temperature distributions. The results show that when the distances between the two targets respectively are 7.5-12.5 mm on the acoustic axis and 2.0-3.0 mm in the direction perpendicular to the acoustic axis, a focal region with a uniform temperature distribution (64-65 ℃) can be created. Moreover, the volume of the focal region formed by one irradiation can be adjusted (26.8-266.7 mm³) along with the uniform temperature distribution. This method may ensure the safety and efficacy of HIFU brain tumor therapy.

关键词: high-intensity focused ultrasound (HIFU), transcranial therapy, double excitation signal superimposition, temperature modulation of focal region

Abstract: Recently, the phase compensation technique has allowed the ultrasound to propagate through the skull and focus into the brain. However, the temperature evolution during treatment is hard to control to achieve effective treatment and avoid over-high temperature. Proposed in this paper is a method to modulate the temperature distribution in the focal region. It superimposes two signals which focus on two preset different targets with a certain distance. Then the temperature distribution is modulated by changing triggering time delay and amplitudes of the two signals. The simulation model is established based on an 82-element transducer and computed tomography (CT) data of a volunteer's head. A finite-difference time-domain (FDTD) method is used to calculate the temperature distributions. The results show that when the distances between the two targets respectively are 7.5-12.5 mm on the acoustic axis and 2.0-3.0 mm in the direction perpendicular to the acoustic axis, a focal region with a uniform temperature distribution (64-65 ℃) can be created. Moreover, the volume of the focal region formed by one irradiation can be adjusted (26.8-266.7 mm³) along with the uniform temperature distribution. This method may ensure the safety and efficacy of HIFU brain tumor therapy.

Key words: high-intensity focused ultrasound (HIFU), transcranial therapy, double excitation signal superimposition, temperature modulation of focal region

中图分类号: (Biological effects of acoustic and ultrasonic energy)

87.50.Y-

87.55.Gh (Simulation) 87.55.dh (Tissue response) 87.55.de (Optimization)

常诗卉, 曹睿, 张亚斌, 王佩国, 吴世敬, 钱宇晗, 菅喜岐. Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound[J]. 中国物理B, 2018, 27(7): 78701-078701.

Shi-Hui Chang(常诗卉), Rui Cao(曹睿), Ya-Bin Zhang(张亚斌), Pei-Guo Wang(王佩国), Shi-Jing Wu(吴世敬), Yu-Han Qian(钱宇晗), Xi-Qi Jian(菅喜岐). Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound[J]. Chin. Phys. B, 2018, 27(7): 78701-078701.

参考文献 51

[1]	Wang H L, Fan P F, Guo X S, Tu J, Ma Y and Zhang D 2016 Chin. Phys. B 25 124314
[2]	Yuan Y, Chen Y D and Li X L 2016 Chin. Phys. B 25 084301
[3]	Wang X D, Lin W J, Su C and Wang X M 2018 Chin. Phys. B 27 024302
[4]	Su H D, Guo G P, Ma Q Y, Tu J and Zhang D 2017 Chin. Phys. B 26 054302
[5]	Hsiao Y H, Kuo S J, Tsai H D, Chou M C and Yeh G P 2016 J. Cancer 7 225
[6]	Kennedy J E 2005 Nat. Rev. Cancer 5 321
[7]	ter Haar G 2007 Prog. Biophys. Mol. Biol. 93 111
[8]	Fry F J 1958 Am. J. Phys. Med. Rehabil. 37 152
[9]	Fry F J, Kossoff G, Eggleton R C and Dunn F 1970 J. Acoust. Soc. Am. 48 1413
[10]	Ding X, Wang Y Z, Zhang Q, Zhou W Z, Wang P G, Luo M Y and Jian X Q 2015 Phys. Med. Biol. 60 3975
[11]	Hynynen K and Jolesz F A 1998 Ultrasound Med. Biol. 24 275
[12]	Marquet F, Pernot M, Aubry J F, Montaldo G, Marsac L, Tanter M and Fink M 2009 Phys. Med. Biol. 54 2597
[13]	Narumi R, Matsuki K, Mitarai S, Azuma T, Okita K, Sasaki A, Yoshinaka K, Takagi S and Matsumoto Y 2013 Jpn. J. Appl. Phys. 52 07HF01-1
[14]	Thomas J L and Fink M A 1996 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 43 1122
[15]	Tanter M, Thomas J L and Fink M 1998 J. Acoust. Soc. Am. 103 2403
[16]	Aubry J F, Tanter M, Pernot M, Thomas J L and Fink M 2003 J. Acoust. Soc. Am. 113 84
[17]	Pernot M, Aubry J F, Tanter M, Andre F and Fink M 2004 IEEE Ultrason. Symp., 23-27 Aug, Montreal, Canada, p. 1005
[18]	Sun J and Hynynen K 1998 J. Acoust. Soc. Am. 104 1705
[19]	Clement G T, Sun J, Giesecke T and Hynynen K 2000 Phys. Med. Biol. 45 3707
[20]	Leduc N, Okita K, Sugiyama K, Takagi S and Matsumoto Y 2012 J. Biomech. Sci. Eng. 7 43
[21]	Coluccia D, Fandino J, Schwyzer L, O'Gorman R, Remonda L, Anon J, Martin E and Werner B 2014 J. Ther. Ultrasound 2 17
[22]	Jeanmonod D, Werner B, Morel A, Michels L, Zadicario E, Schiff G and Martin E 2012 Neurosurg. Focus. 32 E1
[23]	Chang W S, Jung H H, Kweon E J, Zadicario E, Rachmilevitch I and Chang J W 2015 J. Neurol. Neurosurg. Psychiatr 86 257
[24]	Elias W J, Huss D, Voss T, Loomba J, Khaled M, Zadicario E, Frysinger R C, Sperling S A, Wylie S, Monteith S J, Druzgal J, Shah B B, Harrison M and Wintermark M 2013 N. Engl. J. Med. 369 640
[25]	McDannold N, Clement G T, Black P, Jolesz F and Hynynen K 2010 Neurosurgery 66 323
[26]	Martin E and Jolesz F A 2011 Tumors of the Central Nervous System (Dordrecht:Springer Netherlands) pp. 227-236
[27]	Magara A, Buhler R, Moser D, Kowalski M, Pourtehrani P and Jeanmonod D 2014 J. Ther. Ultrasound 2 11
[28]	Ebbini E S and Cain C A 1989 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 36 540
[29]	Salomir R, Palussiere J, Vimeux F C, de Zwart J A, Quesson B, Gauchet M, Lelong P, Pergrale J, Grenier N and Moonen C T 2000 J. Magn. Reson. Imaging 12 571
[30]	Lu M Z, Wan M X, Shi Y and Song Y C 2002 Acta Phys. Sin. 51 928 (in Chinese)
[31]	Xu F, Lu M Z, Wan M X and Fang F 2010 Acta Phys. Sin. 59 1349 (in Chinese)
[32]	Partanen A, Tillander M, Yarmolenko P S, Wood B J, Dreher M R and Kohler M O 2013 Med. Phys. 40 013301-1
[33]	Zhou Y F 2013 Ultrasonics 53 495
[34]	Kohler M O, Mougenot C, Quesson B, Enholm J, Le Bail B, Laurent C, Moonen C T and Ehnholm G J 2009 Med. Phys. 36 3521
[35]	Vincenot J, Melodelima D, Chavrier F, Vignot A, Kocot A and Chapelon J Y 2013 Ultrasound Med. Biol. 39 1241
[36]	Lee K I, Sim I, Kang G S and Choi M J 2008 Mod. Phys. Lett. B 22 803
[37]	Westervelt P J 1963 J. Acoust. Soc. Am. 35 535
[38]	Hallaj I M, Clevel and R O 1999 J. Acoust. Soc. Am. 105 L7
[39]	Pennes H H 1948 J. Appl. Physiol. 1 93
[40]	Sapareto S A and Dewey W C 1984 Int. J. Radiat. Oncol. Biol. Phys. 10 787
[41]	Vykhodtseva N, Sorrentino V, Jolesz F A, Bronson R T and Hynynen K 2000 Ultrasound Med. Biol. 26 871
[42]	Pinton G, Aubry J F, Fink M and Tanter M 2011 Med. Phys. 38 1207
[43]	Clement G T, White P J and Hynynen K 2004 J. Acoust. Soc. Am. 115 1356
[44]	Tao M H 2016 The Numerical Simulation Study on Treatable Focal Region of Transcranial Brain Tumor with High-intensity Focused Ultrasound (MS Thesis) (Tianjin:Tianjin Medical University) (in Chinese)
[45]	Chauvet D, Marsac L, Pernot M, Boch A L, Guillevin R, Salameh N, Souris L, Darrasse L, Fink M, Tanter M and Aubry J F 2013 J. Neurosurg. 118 1046
[46]	Eames M D, Hananel A, Snell J W, Kassell N F and Aubry J F 2014 J. Ther. Ultrasound 1 24
[47]	Ghanouni P, Dobrotwir A, Bazzocchi A, Bucknor M, Bitton R, Rosenberg J, Telischak K, Busacca M, Ferrari S, Albisinni U, Walters S, Gold G, Ganjoo K, Napoli A, Pauly K B and Avedian R 2017 Eur. Radiol. 27 732
[48]	Li J J, Gu M F, Luo G Y, Liu L Z, Zhang R and Xu G L 2009 Technol. Cancer Res. Treat 8 217
[49]	Zhang Y, Aubry J F, Zhang J, Wang Y, Roy J, Mata J F, Miller W, Dumont E, Xie M, Lee K, Zuo Z and Wintermark M 2015 Ultrasound Med. Biol. 41 449
[50]	Fan X and Hynynen K 1996 Ultrasound Med. Biol. 22 471
[51]	Connor C W and Hynynen K 2004 IEEE Trans. Biomed. Eng. 51 1693

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

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