Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model

doi:10.1088/1674-1056/24/12/124302

中国物理B ›› 2015, Vol. 24 ›› Issue (12): 124302-124302.doi: 10.1088/1674-1056/24/12/124302

• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇下一篇

Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model

袁毅^a, 李小俚^{b c}

a Institute of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China;
b State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China;
c Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, China

收稿日期:2015-03-23 修回日期:2015-06-24 出版日期:2015-12-05 发布日期:2015-12-05
通讯作者: Yuan Yi, Li Xiao-Li E-mail:yuanyi513@ysu.edu.cn;xiaoli@bnu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 61273063 and 61503321), the China Postdoctoral Science Foundation (Grant No. 2013M540215), the Natural Science Foundation of Hebei Province, China (Grant No. F2014203161), and the Youth Research Program of Yanshan University, China (Grant No. 02000134).

Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model

Yuan Yi (袁毅)^a, Li Xiao-Li (李小俚)^{b c}

a Institute of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China;
b State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China;
c Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, China

Received:2015-03-23 Revised:2015-06-24 Online:2015-12-05 Published:2015-12-05
Contact: Yuan Yi, Li Xiao-Li E-mail:yuanyi513@ysu.edu.cn;xiaoli@bnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 61273063 and 61503321), the China Postdoctoral Science Foundation (Grant No. 2013M540215), the Natural Science Foundation of Hebei Province, China (Grant No. F2014203161), and the Youth Research Program of Yanshan University, China (Grant No. 02000134).

摘要/Abstract

摘要： Transcranial Hall-effect stimulation (THS) is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field (due to Lorentz force). In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then, based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.

关键词: Hall-effect, stimulation, passive cable model, neurons

Abstract: Transcranial Hall-effect stimulation (THS) is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field (due to Lorentz force). In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then, based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.

Key words: Hall-effect, stimulation, passive cable model, neurons

中图分类号: (Physiological acoustics)

43.64.+r

87.50.Y- (Biological effects of acoustic and ultrasonic energy) 87.50.wf (Biophysical mechanisms of interaction)

袁毅, 李小俚. Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model[J]. 中国物理B, 2015, 24(12): 124302-124302.

Yuan Yi (袁毅), Li Xiao-Li (李小俚). Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model[J]. Chin. Phys. B, 2015, 24(12): 124302-124302.

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Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model

Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model

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