中国物理B ›› 2016, Vol. 25 ›› Issue (8): 84301-084301.doi: 10.1088/1674-1056/25/8/084301
所属专题： Virtual Special Topic — Acoustics
• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇 下一篇
A new brain stimulation method: Noninvasive transcranial magneto-acoustical stimulation
Yi Yuan(袁毅), Yu-Dong Chen(陈玉东), Xiao-Li Li(李小俚)
- 1 Institute of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China;
2 State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China;
3 Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, China
A new brain stimulation method: Noninvasive transcranial magneto-acoustical stimulation
Yi Yuan(袁 毅)1, Yu-Dong Chen(陈玉东)1, Xiao-Li Li(李小俚)2,3
- 1 Institute of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China;
2 State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China;
3 Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, China
摘要：
We investigate transcranial magneto-acoustical stimulation (TMAS) for noninvasive brain neuromodulation in vivo. TMAS as a novel technique uses an ultrasound wave to induce an electric current in the brain tissue in the static magnetic field. It has the advantage of high spatial resolution and penetration depth. The mechanism of TMAS onto a neuron is analyzed by combining the TMAS principle and Hodgkin-Huxley neuron model. The anesthetized rats are stimulated by TMAS, resulting in the local field potentials which are recorded and analyzed. The simulation results show that TMAS can induce neuronal action potential. The experimental results indicate that TMAS can not only increase the amplitude of local field potentials but also enhance the effect of focused ultrasound stimulation on the neuromodulation. In summary, TMAS can accomplish brain neuromodulation, suggesting a potentially powerful noninvasive stimulation method to interfere with brain rhythms for diagnostic and therapeutic purposes.
中图分类号: (Physiological acoustics)
- 43.64.+r