中国物理B ›› 2024, Vol. 33 ›› Issue (2): 28702-028702.doi: 10.1088/1674-1056/ad117c
Yikai Ma(马一凯)1, Na Li(李娜)2,3,†, and Wei Chen(陈唯)1,‡
Yikai Ma(马一凯)1, Na Li(李娜)2,3,†, and Wei Chen(陈唯)1,‡
摘要: Quantitative examination of cellular motion and intercellullar interactions possesses substantial relevance for both biology and medicine. However, the effects of intercellular interactions during cellular locomotion remain under-explored in experimental research. As such, this study seeks to bridge this research gap, adopting Dictyostelium discoideum (Dicty) cells as a paradigm to investigate variations in cellular motion during reciprocal collisions. We aim to attain a comprehensive understanding of how cell interactions influence cell motion. By observing and processing the motion trajectories of colliding cells under diverse chemical environments, we calculated the diffusion coefficient ($D$) and the persistence time ($\tau$), using mean square displacement. Our analysis of the relationship dynamics between $D$ and $\tau $ prior to the collisions reveals intricate and non-monotonic alterations in cell movements during collisions. By quantitatively scrutinizing the $\tau $ trend, we were able to categorize the cellular responses to interactions under different conditions. Importantly, we ascertained that the effect of cell interactions during collisions in Dicty cells emulates a classical sigmoid function. This discovery suggests that cellular responses might comply with a pattern akin to the Weber-Fechner law.
中图分类号: (Cell-cell communication; collective behavior of motile cells)