中国物理B ›› 2024, Vol. 33 ›› Issue (2): 28702-028702.doi: 10.1088/1674-1056/ad117c

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Characteristics of cell motility during cell collision

Yikai Ma(马一凯)1, Na Li(李娜)2,3,†, and Wei Chen(陈唯)1,‡   

  1. 1 State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200438, China;
    2 China National Center for Bioinformation, Beijing 100101, China;
    3 National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
  • 收稿日期:2023-11-06 修回日期:2023-11-10 接受日期:2023-12-01 出版日期:2024-01-16 发布日期:2024-01-19
  • 通讯作者: Na Li, Wei Chen E-mail:694526249@qq.com;phchenwei@fudan.edu.cn
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant No. 31971183).

Characteristics of cell motility during cell collision

Yikai Ma(马一凯)1, Na Li(李娜)2,3,†, and Wei Chen(陈唯)1,‡   

  1. 1 State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200438, China;
    2 China National Center for Bioinformation, Beijing 100101, China;
    3 National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2023-11-06 Revised:2023-11-10 Accepted:2023-12-01 Online:2024-01-16 Published:2024-01-19
  • Contact: Na Li, Wei Chen E-mail:694526249@qq.com;phchenwei@fudan.edu.cn
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant No. 31971183).

摘要: Quantitative examination of cellular motion and intercellullar interactions possesses substantial relevance for both biology and medicine. However, the effects of intercellular interactions during cellular locomotion remain under-explored in experimental research. As such, this study seeks to bridge this research gap, adopting Dictyostelium discoideum (Dicty) cells as a paradigm to investigate variations in cellular motion during reciprocal collisions. We aim to attain a comprehensive understanding of how cell interactions influence cell motion. By observing and processing the motion trajectories of colliding cells under diverse chemical environments, we calculated the diffusion coefficient ($D$) and the persistence time ($\tau$), using mean square displacement. Our analysis of the relationship dynamics between $D$ and $\tau $ prior to the collisions reveals intricate and non-monotonic alterations in cell movements during collisions. By quantitatively scrutinizing the $\tau $ trend, we were able to categorize the cellular responses to interactions under different conditions. Importantly, we ascertained that the effect of cell interactions during collisions in Dicty cells emulates a classical sigmoid function. This discovery suggests that cellular responses might comply with a pattern akin to the Weber-Fechner law.

关键词: cell migration, random walk, cell-cell interaction

Abstract: Quantitative examination of cellular motion and intercellullar interactions possesses substantial relevance for both biology and medicine. However, the effects of intercellular interactions during cellular locomotion remain under-explored in experimental research. As such, this study seeks to bridge this research gap, adopting Dictyostelium discoideum (Dicty) cells as a paradigm to investigate variations in cellular motion during reciprocal collisions. We aim to attain a comprehensive understanding of how cell interactions influence cell motion. By observing and processing the motion trajectories of colliding cells under diverse chemical environments, we calculated the diffusion coefficient ($D$) and the persistence time ($\tau$), using mean square displacement. Our analysis of the relationship dynamics between $D$ and $\tau $ prior to the collisions reveals intricate and non-monotonic alterations in cell movements during collisions. By quantitatively scrutinizing the $\tau $ trend, we were able to categorize the cellular responses to interactions under different conditions. Importantly, we ascertained that the effect of cell interactions during collisions in Dicty cells emulates a classical sigmoid function. This discovery suggests that cellular responses might comply with a pattern akin to the Weber-Fechner law.

Key words: cell migration, random walk, cell-cell interaction

中图分类号:  (Cell-cell communication; collective behavior of motile cells)

  • 87.18.Gh
87.17.Jj (Cell locomotion, chemotaxis) 05.40.Jc (Brownian motion) 05.40.-a (Fluctuation phenomena, random processes, noise, and Brownian motion)