中国物理B ›› 2023, Vol. 32 ›› Issue (11): 118705-118705.doi: 10.1088/1674-1056/acf704

所属专题: SPECIAL TOPIC — Celebrating the 100th Anniversary of Physics Discipline of Northwest University

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Directional-to-random transition of cell cluster migration

Yang Zeng(曾阳)1,†, Bingchen Che(车丙晨)2,†, Dan Sun(孙聃)1,†, Ce Zhang(张策)1,‡, and Guangyin Jing(经光银)2,§   

  1. 1 State Key Laboratory of Photon-Technology in Western China Energy, Institute of Photonics and Photon-Technology, Northwest University, Xi'an 710127, China;
    2 School of Physics, Northwest University, Xi'an 710127, China
  • 收稿日期:2023-06-30 修回日期:2023-09-04 接受日期:2023-09-06 出版日期:2023-10-16 发布日期:2023-11-07
  • 通讯作者: Ce Zhang, Guangyin Jing E-mail:zhangce.univ@gmail.com;jing@nwu.edu.cn
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 51927804 and 12174306) and the Natural Science Basic Research Program of Shaanxi Province of China (Grant No. 2023-JC-JQ-02).

Directional-to-random transition of cell cluster migration

Yang Zeng(曾阳)1,†, Bingchen Che(车丙晨)2,†, Dan Sun(孙聃)1,†, Ce Zhang(张策)1,‡, and Guangyin Jing(经光银)2,§   

  1. 1 State Key Laboratory of Photon-Technology in Western China Energy, Institute of Photonics and Photon-Technology, Northwest University, Xi'an 710127, China;
    2 School of Physics, Northwest University, Xi'an 710127, China
  • Received:2023-06-30 Revised:2023-09-04 Accepted:2023-09-06 Online:2023-10-16 Published:2023-11-07
  • Contact: Ce Zhang, Guangyin Jing E-mail:zhangce.univ@gmail.com;jing@nwu.edu.cn
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 51927804 and 12174306) and the Natural Science Basic Research Program of Shaanxi Province of China (Grant No. 2023-JC-JQ-02).

摘要: Efficient cell migration is crucial for the functioning of biological processes, e.g., morphogenesis, wound healing, and cancer metastasis. In this study, we monitor the migratory behavior of the 3D fibroblast clusters using live cell microscopy, and find that crowded environment affects cell migration, i.e., crowding leads to directional migration at the cluster's periphery. The number of cell layers being stacked during seeding determines the directional-to-random transition. Intriguingly, the migratory behavior of cell clusters resembles the dispersion dynamics of clouds of passive particles, indicating that the biological process is driven by physical effects (e.g., entropy) rather than cell communication. Our findings highlight the role of intrinsic physical characteristics, such as crowding, in regulating biological behavior, and suggest new therapeutic approaches targeting at cancer metastasis.

关键词: cell migration, random walk, active wetting, cell cluster

Abstract: Efficient cell migration is crucial for the functioning of biological processes, e.g., morphogenesis, wound healing, and cancer metastasis. In this study, we monitor the migratory behavior of the 3D fibroblast clusters using live cell microscopy, and find that crowded environment affects cell migration, i.e., crowding leads to directional migration at the cluster's periphery. The number of cell layers being stacked during seeding determines the directional-to-random transition. Intriguingly, the migratory behavior of cell clusters resembles the dispersion dynamics of clouds of passive particles, indicating that the biological process is driven by physical effects (e.g., entropy) rather than cell communication. Our findings highlight the role of intrinsic physical characteristics, such as crowding, in regulating biological behavior, and suggest new therapeutic approaches targeting at cancer metastasis.

Key words: cell migration, random walk, active wetting, cell cluster

中图分类号:  (Cell aggregation)

  • 87.18.Ed
05.40.Fb (Random walks and Levy flights) 68.08.Bc (Wetting) 87.17.Jj (Cell locomotion, chemotaxis)