Effect of elasticity mismatch on cell deformation and migration: A phase-field study

doi:10.1088/1674-1056/27/11/116201

中国物理B ›› 2018, Vol. 27 ›› Issue (11): 116201-116201.doi: 10.1088/1674-1056/27/11/116201

所属专题： SPECIAL TOPIC — 80th Anniversary of Northwestern Polytechnical University (NPU)

• SPECIAL TOPIC—Recent advances in thermoelectric materials and devices • 上一篇下一篇

Effect of elasticity mismatch on cell deformation and migration: A phase-field study

Yuanfeng Yin(尹元枫), Hui Xing(邢辉), Duyang Zang(臧渡洋), Kexin Jin(金克新)

1 MOE Key Laboratory of Material Physics and Chemistry under Extraordinary, Northwestern Polytechnical University, Xi'an 710129, China;
2 Shaanxi Key Laboratory for Condensed Matter Structure and Properties, Northwestern Polytechnical University, Xi'an 710129, China

收稿日期:2018-07-06 修回日期:2018-08-27 出版日期:2018-11-05 发布日期:2018-11-05
通讯作者: Hui Xing E-mail:huixing@nwpu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 51701160 and U1732129) and the Fundamental Research Funds for the Central Universities, China (Grant No. 3102018zy046).

Effect of elasticity mismatch on cell deformation and migration: A phase-field study

Yuanfeng Yin(尹元枫)^1,2, Hui Xing(邢辉)^1,2, Duyang Zang(臧渡洋)^1,2, Kexin Jin(金克新)^1,2

1 MOE Key Laboratory of Material Physics and Chemistry under Extraordinary, Northwestern Polytechnical University, Xi'an 710129, China;
2 Shaanxi Key Laboratory for Condensed Matter Structure and Properties, Northwestern Polytechnical University, Xi'an 710129, China

Received:2018-07-06 Revised:2018-08-27 Online:2018-11-05 Published:2018-11-05
Contact: Hui Xing E-mail:huixing@nwpu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 51701160 and U1732129) and the Fundamental Research Funds for the Central Universities, China (Grant No. 3102018zy046).

摘要/Abstract

摘要：

The phase-field model for cell migration is used to study the effect of elasticity mismatch on the migration dynamics of multiple cells in a confluent monolayer, where one tagged cell is embedded by a number of normal cells and both types of cells are supposed to have the same properties except elasticity. Our results show that a larger elasticity mismatch leads to a larger difference in shape change between the tagged cell and the normal cells. We find that the bursts of velocity always fall behind the peak of the perimeter, and the shape change of the tagged cell results in the accelerated motion of the tagged cell in the whole process. Moreover, the variation of the averaging cell perimeter ratio L_tag/L_normal with the increase of the elasticity ratio γ_tag/γ_normal for different active velocities|v_a|is analyzed. We find that L_tag/L_normal decreases with the increase of γ_tag/γ_normal, following a simple power law function. Our results highlight the important role played by the cell elasticity mismatch in cell deformation and migration.

关键词: cell migration, elastic mismatch, phase-field simulations

Abstract:

Key words: cell migration, elastic mismatch, phase-field simulations

中图分类号: (Elasticity)

62.20.D-

62.20.F- (Deformation and plasticity) 64.70.qd (Thermodynamics and statistical mechanics)

尹元枫, 邢辉, 臧渡洋, 金克新. Effect of elasticity mismatch on cell deformation and migration: A phase-field study[J]. 中国物理B, 2018, 27(11): 116201-116201.

Yuanfeng Yin(尹元枫), Hui Xing(邢辉), Duyang Zang(臧渡洋), Kexin Jin(金克新). Effect of elasticity mismatch on cell deformation and migration: A phase-field study[J]. Chin. Phys. B, 2018, 27(11): 116201-116201.

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Effect of elasticity mismatch on cell deformation and migration: A phase-field study

Effect of elasticity mismatch on cell deformation and migration: A phase-field study

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