中国物理B ›› 2021, Vol. 30 ›› Issue (9): 90502-090502.doi: 10.1088/1674-1056/abf557
Migration and shape of cells on different interfaces
Xiaochen Wang(王晓晨)1,2, Qihui Fan (樊琪慧)1, and Fangfu Ye(叶方富)1,2,3,4,†
- 1 Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;
2 School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
3 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China;
4 Songshan Lake Materials Laboratory, Dongguan 523808, China
Migration and shape of cells on different interfaces
Xiaochen Wang(王晓晨)1,2, Qihui Fan (樊琪慧)1, and Fangfu Ye(叶方富)1,2,3,4,†
- 1 Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;
2 School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
3 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China;
4 Songshan Lake Materials Laboratory, Dongguan 523808, China
摘要： Impacts of microenvironments on cell migration have been reported in various interaction modes. A rapid tumor metastasis occurs along topological interfaces in vivo, such as the interface between the blood vessels and nerves. In this work, we culture MDA-MB231 cells at dish-liquid, dish-hydrogel, and hydrogel-liquid interfaces, respectively, to study how these different interfaces influence cell dynamics and morphology. Our results show that the migration mode of cells changes from an amoeboid motion to a mesenchymal motion but their speed do not change obviously if the interface changes from hydrogel-liquid to dish-liquid. In contrast, the migration mode of cells at a dish-hydrogel interface maintains as a mesenchymal motion, whereas their speed increases significantly.
中图分类号: (Brownian motion)
- 05.40.Jc