中国物理B ›› 2026, Vol. 35 ›› Issue (6): 68703-068703.doi: 10.1088/1674-1056/ae4e8c

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Anti-interference ability of spiking neuron-astrocyte networks in working memory

Lin Li(李琳)1, Bingyi Mo(莫冰毅)1, Shanshan Cheng(程姗姗)1, Zhouchao Wei(魏周超)2, Ming Yi(易鸣)1, and Lulu Lu(鹿露露)1,†   

  1. 1 School of Mathematics and Physics, China University of Geosciences, Wuhan 430074, China;
    2 Institute for Advanced Marine Research, China University of Geosciences, Guangzhou 511462, China
  • 收稿日期:2026-01-16 修回日期:2026-03-05 接受日期:2026-03-07 发布日期:2026-06-05
  • 通讯作者: Lulu Lu E-mail:lululu@cug.edu.cn
  • 基金资助:
    This study was supported by the National Natural Science Foundation of China (Grant Nos. 12305054 and 12572032), the Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems (Grant No. 2024B1212010004), and the Fundamental Research Funds for Central Universities, China University of Geosciences (Wuhan) (Grant No. CUGQT2023001).

Anti-interference ability of spiking neuron-astrocyte networks in working memory

Lin Li(李琳)1, Bingyi Mo(莫冰毅)1, Shanshan Cheng(程姗姗)1, Zhouchao Wei(魏周超)2, Ming Yi(易鸣)1, and Lulu Lu(鹿露露)1,†   

  1. 1 School of Mathematics and Physics, China University of Geosciences, Wuhan 430074, China;
    2 Institute for Advanced Marine Research, China University of Geosciences, Guangzhou 511462, China
  • Received:2026-01-16 Revised:2026-03-05 Accepted:2026-03-07 Published:2026-06-05
  • Contact: Lulu Lu E-mail:lululu@cug.edu.cn
  • Supported by:
    This study was supported by the National Natural Science Foundation of China (Grant Nos. 12305054 and 12572032), the Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems (Grant No. 2024B1212010004), and the Fundamental Research Funds for Central Universities, China University of Geosciences (Wuhan) (Grant No. CUGQT2023001).

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摘要： Working memory is a fundamental aspect of brain cognitive function. Its anti-interference ability relies on the network structure and the balance between excitatory and inhibitory neurons in neural systems. Here, we discuss the resistance of the spiking neuron-astrocyte network (SNAN) to noise interference of the input signal during working memory tasks, and we underscore that astrocytes play an essential regulatory role in synaptic plasticity. These results indicate that, compared to the SNAN and spiking neuron network (SNN), the improved SNAN incorporated 2-Arachidonoylglycerol (2-AG) modulation displays notable resistance to high noise interference. The improved SNAN shows optimal working memory performance, demonstrating a greater correlation between recalled patterns and input patterns. This may be due to the reduced connection sparsity of the neural network and decreased neural firing frequency caused by 2-AG, as well as its simultaneous impact on the secretion of glutamate. At the same time, astrocytes affecting memory maintenance generate overlapping calcium signals in multi-task working memory. In addition, astrocytes can significantly enhance working memory performance by modulating synaptic coupling under high noise interference. This study may provide insights into understanding the role of astrocytes in the neural mechanisms of working memory and information processing.

关键词: working memory, astrocytes, anti-interference ability, spiking neuron-astrocyte network, synaptic plasticity

Abstract: Working memory is a fundamental aspect of brain cognitive function. Its anti-interference ability relies on the network structure and the balance between excitatory and inhibitory neurons in neural systems. Here, we discuss the resistance of the spiking neuron-astrocyte network (SNAN) to noise interference of the input signal during working memory tasks, and we underscore that astrocytes play an essential regulatory role in synaptic plasticity. These results indicate that, compared to the SNAN and spiking neuron network (SNN), the improved SNAN incorporated 2-Arachidonoylglycerol (2-AG) modulation displays notable resistance to high noise interference. The improved SNAN shows optimal working memory performance, demonstrating a greater correlation between recalled patterns and input patterns. This may be due to the reduced connection sparsity of the neural network and decreased neural firing frequency caused by 2-AG, as well as its simultaneous impact on the secretion of glutamate. At the same time, astrocytes affecting memory maintenance generate overlapping calcium signals in multi-task working memory. In addition, astrocytes can significantly enhance working memory performance by modulating synaptic coupling under high noise interference. This study may provide insights into understanding the role of astrocytes in the neural mechanisms of working memory and information processing.

Key words: working memory, astrocytes, anti-interference ability, spiking neuron-astrocyte network, synaptic plasticity

中图分类号:  (Neuroscience)

  • 87.19.L-
05.45.-a (Nonlinear dynamics and chaos) 87.19.ll (Models of single neurons and networks) 87.19.lw (Plasticity)