Mechanical activation of DNA transport across single-walled carbon nanotubes

doi:10.1088/1674-1056/adce9b

中国物理B ›› 2025, Vol. 34 ›› Issue (10): 108701-108701.doi: 10.1088/1674-1056/adce9b

Mechanical activation of DNA transport across single-walled carbon nanotubes

Junjie Gao(高俊杰), Yichao Wu(吴逸超), Siqi Yu(俞斯棋), Xiaoyan Zhou(周晓艳)†, and Hangjun Lu(陆杭军)‡

Department of Physics, Zhejiang Normal University, Jinhua 321004, China

收稿日期:2025-02-19 修回日期:2025-04-12 接受日期:2025-04-21 发布日期:2025-10-09
通讯作者: Xiaoyan Zhou, Hangjun Lu E-mail:zxylu@zjnu.cn;zjlhjun@zjnu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 11875237).

Mechanical activation of DNA transport across single-walled carbon nanotubes

Junjie Gao(高俊杰), Yichao Wu(吴逸超), Siqi Yu(俞斯棋), Xiaoyan Zhou(周晓艳)†, and Hangjun Lu(陆杭军)‡

Department of Physics, Zhejiang Normal University, Jinhua 321004, China

Received:2025-02-19 Revised:2025-04-12 Accepted:2025-04-21 Published:2025-10-09
Contact: Xiaoyan Zhou, Hangjun Lu E-mail:zxylu@zjnu.cn;zjlhjun@zjnu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 11875237).

摘要/Abstract

摘要： We employed molecular dynamics simulations to investigate the directed transport of a double-stranded oligonucleotide (dsDNA) through a single-walled carbon nanotube (SWNT) powered by external mechanical vibrations. It is thermodynamically favorable for dsDNA to adsorb inside the SWNT, and its transport through the nanotube is challenging due to the high energy barrier. However, we demonstrate that mechanical vibrations at specific frequencies can effectively drive the dsDNA through the nanotube based on a ratchet effect. The system is driven away from thermal equilibrium, and the spatial inversion symmetry is broken by mechanical vibrations. This study provides valuable insights into the mechanisms of mechanically activated DNA transport and highlights the potential of using SWNTs as nanoscale conduits for dsDNA delivery in nanobiotechnology and biomedicine.

关键词: double-stranded oligonucleotide (dsDNA), single-walled carbon nanotube (SWNT), mechanical vibrations, ratchet effect

Abstract: We employed molecular dynamics simulations to investigate the directed transport of a double-stranded oligonucleotide (dsDNA) through a single-walled carbon nanotube (SWNT) powered by external mechanical vibrations. It is thermodynamically favorable for dsDNA to adsorb inside the SWNT, and its transport through the nanotube is challenging due to the high energy barrier. However, we demonstrate that mechanical vibrations at specific frequencies can effectively drive the dsDNA through the nanotube based on a ratchet effect. The system is driven away from thermal equilibrium, and the spatial inversion symmetry is broken by mechanical vibrations. This study provides valuable insights into the mechanisms of mechanically activated DNA transport and highlights the potential of using SWNTs as nanoscale conduits for dsDNA delivery in nanobiotechnology and biomedicine.

Key words: double-stranded oligonucleotide (dsDNA), single-walled carbon nanotube (SWNT), mechanical vibrations, ratchet effect

中图分类号: (DNA)

87.14.gk

87.15.ap (Molecular dynamics simulation) 87.85.Rs (Nanotechnologies-applications) 05.40.-a (Fluctuation phenomena, random processes, noise, and Brownian motion)

Junjie Gao(高俊杰), Yichao Wu(吴逸超), Siqi Yu(俞斯棋), Xiaoyan Zhou(周晓艳), and Hangjun Lu(陆杭军). Mechanical activation of DNA transport across single-walled carbon nanotubes[J]. 中国物理B, 2025, 34(10): 108701-108701.

Junjie Gao(高俊杰), Yichao Wu(吴逸超), Siqi Yu(俞斯棋), Xiaoyan Zhou(周晓艳), and Hangjun Lu(陆杭军). Mechanical activation of DNA transport across single-walled carbon nanotubes[J]. Chin. Phys. B, 2025, 34(10): 108701-108701.

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Mechanical activation of DNA transport across single-walled carbon nanotubes

Mechanical activation of DNA transport across single-walled carbon nanotubes

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