Modulation and control of DNA charge inversion

doi:10.1088/1674-1056/26/12/128706

中国物理B ›› 2017, Vol. 26 ›› Issue (12): 128706-128706.doi: 10.1088/1674-1056/26/12/128706

所属专题： TOPICAL REVIEW — Soft matter and biological physics

• SPECIAL TOPIC—Non-equilibrium phenomena in soft matters • 上一篇下一篇

Modulation and control of DNA charge inversion

Yan-Wei Wang(王艳伟), Guang-Can Yang(杨光参)

Department of Physics, Wenzhou University, Wenzhou 325035, China

收稿日期:2017-08-31 修回日期:2017-10-13 出版日期:2017-12-05 发布日期:2017-12-05
通讯作者: Guang-Can Yang E-mail:Yanggc@wzu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11274245, 10974146, and 11304232), the Natural Science Foundation of Zhejiang Provice, China (Grant No. LY17A040006), and the Wenzhou Science and Technology Project, China (Grant No. S20160011).

Modulation and control of DNA charge inversion

Yan-Wei Wang(王艳伟), Guang-Can Yang(杨光参)

Department of Physics, Wenzhou University, Wenzhou 325035, China

Received:2017-08-31 Revised:2017-10-13 Online:2017-12-05 Published:2017-12-05
Contact: Guang-Can Yang E-mail:Yanggc@wzu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11274245, 10974146, and 11304232), the Natural Science Foundation of Zhejiang Provice, China (Grant No. LY17A040006), and the Wenzhou Science and Technology Project, China (Grant No. S20160011).

摘要/Abstract

摘要：

DNA is one of most important biological polyelectrolytes, which is negatively charged in physiological condition. Most of Its charge is neutralized by attracting cations in solution. In some conditions, the effective charge of DNA switches its sign from negative to positive, implying charge inversion of DNA. The underlying microscopic mechanism of the counterintuitive phenomenon is still not fully understood although specific chemical affinity and electrostatic ion correlation are considered as two possible driving forces. In this review, we present some recent experimental progress in the modulation and control of DNA charge by single molecular techniques. It has been shown that DNA charge inversion can be modulated bidirectionly by decreasing or increasing the dielectric constant of solution to make the electrophoretic mobility of DNA increase from a negative value to a positive value. In this meanwhile, charge inversion and condensation of DNA in solution of trivalent and quadrivalent counterions are significantly influenced by pH value of the solution. When mixing quadrivalent counterion with mono-, di-and tri-valent counterions in solution, suppression and promotion of DNA charge inversion can be observed. In addition, hydrophobic effect can play an important role in DNA charge inversiton and compaction. We show that the organic monovalent ions of tetraphenyl chloride arsenic (Ph₄As⁺) can induce DNA compaction and even invert its electrophoretic mobility. Thus, hydrophobic effect can be the main driving force of DNA charge inversion and compaction by the organic monovalent ion.

关键词: charge inversion, counterions, dielectric constant, pH value, hydrophobicity

Abstract:

Key words: charge inversion, counterions, dielectric constant, pH value, hydrophobicity

中图分类号: (DNA)

87.14.gk

87.15.hp (Conformational changes) 82.37.Rs (Single molecule manipulation of proteins and other biological molecules) 82.35.Rs (Polyelectrolytes)

王艳伟, 杨光参. Modulation and control of DNA charge inversion[J]. 中国物理B, 2017, 26(12): 128706-128706.

Yan-Wei Wang(王艳伟), Guang-Can Yang(杨光参). Modulation and control of DNA charge inversion[J]. Chin. Phys. B, 2017, 26(12): 128706-128706.

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Modulation and control of DNA charge inversion

Modulation and control of DNA charge inversion

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