Detection of HIV-1 antigen based on magnetic tunnel junction sensors

doi:10.1088/1674-1056/ab928d

中国物理B ›› 2020, Vol. 29 ›› Issue (8): 88701-088701.doi: 10.1088/1674-1056/ab928d

• SPECIAL TOPIC—Ultracold atom and its application in precision measurement • 上一篇下一篇

Detection of HIV-1 antigen based on magnetic tunnel junction sensors

Li Li(李丽), Kai-Yu Mak(麦启宇), Yan Zhou(周艳)

1 School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China;
2 Hefei National Laboratory for Physical Sciences at the Microscale, Department of Physics, University of Science and Technology of China, Hefei 230026, China

收稿日期:2020-03-17 修回日期:2020-05-05 出版日期:2020-08-05 发布日期:2020-08-05
通讯作者: Yan Zhou E-mail:zhouyan@cuhk.edu.cn
基金资助:
Project supported by President's Fund of CUHKSZ, Longgang Key Laboratory of Applied Spintronics, at The Chinese University of Hong Kong, the National Natural Science Foundation of China (Grant Nos. 11974298 and 61961136006), the Shenzhen Fundamental Research Fund, China (Grant No. JCYJ20170410171958839), and Shenzhen Peacock Group Plan, China (Grant No. KQTD20180413181702403).

Detection of HIV-1 antigen based on magnetic tunnel junction sensors

Li Li(李丽)^1,2, Kai-Yu Mak(麦启宇)¹, Yan Zhou(周艳)¹

1 School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China;
2 Hefei National Laboratory for Physical Sciences at the Microscale, Department of Physics, University of Science and Technology of China, Hefei 230026, China

Received:2020-03-17 Revised:2020-05-05 Online:2020-08-05 Published:2020-08-05
Contact: Yan Zhou E-mail:zhouyan@cuhk.edu.cn
Supported by:
Project supported by President's Fund of CUHKSZ, Longgang Key Laboratory of Applied Spintronics, at The Chinese University of Hong Kong, the National Natural Science Foundation of China (Grant Nos. 11974298 and 61961136006), the Shenzhen Fundamental Research Fund, China (Grant No. JCYJ20170410171958839), and Shenzhen Peacock Group Plan, China (Grant No. KQTD20180413181702403).

摘要/Abstract

摘要：

We report a p24 (HIV disease biomarker) detection assay using an MgO-based magnetic tunnel junction (MTJ) sensor and 20-nm magnetic nanoparticles. The MTJ array sensor with sensing area of 890×890 μ² possessing a sensitivity of 1.39%/Oe was used to detect p24 antigens. It is demonstrated that the p24 antigens could be detected at a concentration of 0.01 μg/ml. The development of bio-detection systems based on magnetic tunnel junction sensors with high-sensitivity will greatly benefit the early diagnosis of HIV.

关键词: MgO-based magnetic tunnel junction sensor, HIV bio-detection system, antigen p24, early disease diagnosis

Abstract:

Key words: MgO-based magnetic tunnel junction sensor, HIV bio-detection system, antigen p24, early disease diagnosis

中图分类号: (Nanotechnologies-applications)

87.85.Rs

87.85.Qr (Nanotechnologies-design) 85.75.Ss (Magnetic field sensors using spin polarized transport) 87.85.fk (Biosensors)

李丽, 麦启宇, 周艳. Detection of HIV-1 antigen based on magnetic tunnel junction sensors[J]. 中国物理B, 2020, 29(8): 88701-088701.

Li Li(李丽), Kai-Yu Mak(麦启宇), Yan Zhou(周艳). Detection of HIV-1 antigen based on magnetic tunnel junction sensors[J]. Chin. Phys. B, 2020, 29(8): 88701-088701.

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Detection of HIV-1 antigen based on magnetic tunnel junction sensors

Detection of HIV-1 antigen based on magnetic tunnel junction sensors

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