中国物理B ›› 2013, Vol. 22 ›› Issue (12): 127503-127503.doi: 10.1088/1674-1056/22/12/127503

所属专题： TOPICAL REVIEW — Magnetism, magnetic materials, and interdisciplinary research

• SPECIAL TOPIC --- Non-equilibrium phenomena in soft matters • 上一篇    下一篇

Toxicity of superparamagnetic iron oxide nanoparticles：Research strategies and implications for nanomedicine

李蕾a, 江玲玲a, 曾云a b, 刘刚a   

  1. a Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China;
    b Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong 637007, China
  • 收稿日期:2013-09-13 发布日期:2013-12-25
  • 基金资助:
    Project supported by the Major State Basic Research Development Program of China (Grant Nos. 2013CB733802 and 2014CB744503), the National Natural Science Foundation of China (Grant Nos. 81101101 and 51273165), the Key Project of Chinese Ministry of Education (Grant No. 212149), and the Fundamental Research Funds for the Central Universities, China (Grant Nos. 2013121039 and ZK1002).

Toxicity of superparamagnetic iron oxide nanoparticles：Research strategies and implications for nanomedicine

Li Lei (李蕾)a, Jiang Ling-Ling (江玲玲)a, Zeng Yun (曾云)a b, Liu Gang (刘刚)a   

  1. a Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China;
    b Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong 637007, China
  • Received:2013-09-13 Published:2013-12-25
  • Contact: Liu Gang E-mail:gangliu.cmitm@xmu.edu.cn
  • Supported by:
    Project supported by the Major State Basic Research Development Program of China (Grant Nos. 2013CB733802 and 2014CB744503), the National Natural Science Foundation of China (Grant Nos. 81101101 and 51273165), the Key Project of Chinese Ministry of Education (Grant No. 212149), and the Fundamental Research Funds for the Central Universities, China (Grant Nos. 2013121039 and ZK1002).

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摘要： Superparamagnetic iron oxide nanoparticles (SPIONs) are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.

关键词: superparamagnetic iron oxide nanoparticle, nanotoxicity, cytotoxicity, oxidative stress, reactive oxygen species

Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.

Key words: superparamagnetic iron oxide nanoparticle, nanotoxicity, cytotoxicity, oxidative stress, reactive oxygen species

中图分类号:  (Studies of specific magnetic materials)

  • 75.50.-y
87.85.J- (Biomaterials) 87.85.jj (Biocompatibility) 87.85.Rs (Nanotechnologies-applications)