Cross-frequency network analysis of functional brain connectivity in temporal lobe epilepsy

doi:10.1088/1674-1056/28/4/048702

中国物理B ›› 2019, Vol. 28 ›› Issue (4): 48702-048702.doi: 10.1088/1674-1056/28/4/048702

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇下一篇

Cross-frequency network analysis of functional brain connectivity in temporal lobe epilepsy

Hai-Tao Yu(于海涛), Li-Hui Cai(蔡立辉), Xin-Yu Wu(武欣昱), Jiang Wang(王江), Jing Liu(刘静), Hong Zhang(张宏)

1 School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China;
2 Department of Neurology, Tangshan Gongren Hospital, Tangshan 063000, China

收稿日期:2018-12-25 修回日期:2019-01-21 出版日期:2019-04-05 发布日期:2019-04-05
通讯作者: Hong Zhang E-mail:zhanghong063000@163.com
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 61302002).

Cross-frequency network analysis of functional brain connectivity in temporal lobe epilepsy

Hai-Tao Yu(于海涛)¹, Li-Hui Cai(蔡立辉)¹, Xin-Yu Wu(武欣昱)¹, Jiang Wang(王江)¹, Jing Liu(刘静)², Hong Zhang(张宏)²

1 School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China;
2 Department of Neurology, Tangshan Gongren Hospital, Tangshan 063000, China

Received:2018-12-25 Revised:2019-01-21 Online:2019-04-05 Published:2019-04-05
Contact: Hong Zhang E-mail:zhanghong063000@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 61302002).

摘要/Abstract

摘要：

In this study, we investigate the cross-frequency coupling and functional brain networks in the subjects with temporal lobe epilepsy (TLE) using interictal EEG signals. The phase to phase synchronization within and across frequency bands is calculated and a significant difference between the epilepsy and control groups is observed. Compared with the controls, the epilepsy patients exhibit a stronger within-frequency coupling (WFC) within theta and beta bands, and shows a stronger cross-frequency coupling (CFC) in the delta-alpha and theta-alpha band pairs, but a weakened CFC in alpha-beta band pairs. The weakened coupling between alpha and high frequency band reflects a suppression of phase modulation between the brain regions related to epilepsy. Moreover, WFC and CFC are positively correlated, which is higher in the patients relative to controls. We further reconstruct functional brain connectivity and find that both WFC and CFC networks show small-world properties. For the epilepsy, the small-world efficiency is enhanced in the CFC networks in delta-alpha and theta-alpha band pairs, whereas weakened between alpha and beta bands, which suggests a shift away from the optimal operating point in the epileptic brain with a new balance between WFC and CFC. Our results may help us to understand the important role of information communication across different frequency bands and shed new light on the study of pathology of epilepsy.

关键词: cross-frequency coupling, epilepsy, functional connectivity, phase synchronization

Abstract:

Key words: cross-frequency coupling, epilepsy, functional connectivity, phase synchronization

中图分类号: (EEG and MEG)

87.19.le

87.19.xm (Epilepsy)

于海涛, 蔡立辉, 武欣昱, 王江, 刘静, 张宏. Cross-frequency network analysis of functional brain connectivity in temporal lobe epilepsy[J]. 中国物理B, 2019, 28(4): 48702-048702.

Hai-Tao Yu(于海涛), Li-Hui Cai(蔡立辉), Xin-Yu Wu(武欣昱), Jiang Wang(王江), Jing Liu(刘静), Hong Zhang(张宏). Cross-frequency network analysis of functional brain connectivity in temporal lobe epilepsy[J]. Chin. Phys. B, 2019, 28(4): 48702-048702.

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Cross-frequency network analysis of functional brain connectivity in temporal lobe epilepsy

Cross-frequency network analysis of functional brain connectivity in temporal lobe epilepsy

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