中国物理B ›› 2013, Vol. 22 ›› Issue (2): 27506-027506.doi: 10.1088/1674-1056/22/2/027506

所属专题: TOPICAL REVIEW — Magnetism, magnetic materials, and interdisciplinary research

• SPECIAL TOPIC --- Non-equilibrium phenomena in soft matters • 上一篇    下一篇

Magnetic nanoparticle-based cancer therapy

余靓a, 黄冬雁b, Muhammad Zubair Yousafa, 侯仰龙a, 高松c   

  1. a Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China;
    b Department of Otorhinolaryngology Head & Neck Surgery, Clinical Division of Surgery, Chinese PLA (People’s Liberation Army) General Hospital, Beijing 100853, China;
    c College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • 收稿日期:2012-12-31 出版日期:2013-01-01 发布日期:2013-01-01
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 51125001, 51172005, and 90922033), the Research Fellowship for International Young Scientists of the National Natural Science Foundation of China (Grant No. 51250110078), the Doctoral Program of the Education Ministry of China (Grant No. 20120001110078), and PKU COE-Health Science Center Seed Fund.

Magnetic nanoparticle-based cancer therapy

Yu Jing (余靓)a, Huang Dong-Yan (黄冬雁)b, Muhammad Zubair Yousafa, Hou Yang-Long (侯仰龙)a, Gao Song (高松)c   

  1. a Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China;
    b Department of Otorhinolaryngology Head & Neck Surgery, Clinical Division of Surgery, Chinese PLA (People’s Liberation Army) General Hospital, Beijing 100853, China;
    c College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2012-12-31 Online:2013-01-01 Published:2013-01-01
  • Contact: Hou Yang-Long E-mail:hou@pku.edu.cn
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 51125001, 51172005, and 90922033), the Research Fellowship for International Young Scientists of the National Natural Science Foundation of China (Grant No. 51250110078), the Doctoral Program of the Education Ministry of China (Grant No. 20120001110078), and PKU COE-Health Science Center Seed Fund.

摘要: Nanoparticles (NPs) with easily modified surfaces have been playing an important role in biomedicine. As cancer is one of the major causes of death, tremendous efforts have been devoted to advance the methods of cancer diagnosis and therapy. Recently, magnetic nanoparticles (MNPs) that are responsive to a magnetic field have shown great promise in cancer therapy. Compared with traditional cancer therapy, magnetic field triggered therapeutic approaches can treat cancer in an unconventional but more effective and safer way. In this review, we will discuss the recent progress in cancer therapies based on MNPs, mainly including magnetic hyperthermia, magnetic specific targeting, magnetically controlled drug delivery, magnetofection, and magnetic switches for controlling cell fate. Some recently developed strategies such as magnetic resonance imaging (MRI) monitoring cancer therapy and magnetic tissue engineering are also addressed.

关键词: magnetic nanoparticles, cancer therapy, hyperthermia, drug delivery, targeting, magnetic resonance imaging

Abstract: Nanoparticles (NPs) with easily modified surfaces have been playing an important role in biomedicine. As cancer is one of the major causes of death, tremendous efforts have been devoted to advance the methods of cancer diagnosis and therapy. Recently, magnetic nanoparticles (MNPs) that are responsive to a magnetic field have shown great promise in cancer therapy. Compared with traditional cancer therapy, magnetic field triggered therapeutic approaches can treat cancer in an unconventional but more effective and safer way. In this review, we will discuss the recent progress in cancer therapies based on MNPs, mainly including magnetic hyperthermia, magnetic specific targeting, magnetically controlled drug delivery, magnetofection, and magnetic switches for controlling cell fate. Some recently developed strategies such as magnetic resonance imaging (MRI) monitoring cancer therapy and magnetic tissue engineering are also addressed.

Key words: magnetic nanoparticles, cancer therapy, hyperthermia, drug delivery, targeting, magnetic resonance imaging

中图分类号: 

  • 75.75.c
87.85.Qr (Nanotechnologies-design)