Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor

doi:10.1088/1674-1056/26/9/098102

中国物理B ›› 2017, Vol. 26 ›› Issue (9): 98102-098102.doi: 10.1088/1674-1056/26/9/098102

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇下一篇

Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor

Jiao-Jiao Liu(刘娇娇), Qi Chang(常琪), Mei-Mei Bao(鲍美美), Bing Yuan(元冰), Kai Yang(杨恺), Yu-Qiang Ma(马余强)

1 Center for Soft Condensed Matter Physics and Interdisciplinary Research, College of Physics, Optoelectronics and Energy, Soochow University, Suzhou 215006, China;
2 National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, China

收稿日期:2017-05-04 修回日期:2017-05-18 出版日期:2017-09-05 发布日期:2017-09-05
通讯作者: Bing Yuan, Kai Yang E-mail:yuanbing@suda.edu.cn;yangkai@suda.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 21374074, 21422404, and U1532108) and the Undergraduate Training Program for Innovation and Entrepreneurship of Soochow University, China (Grant No. 2016xj010).

Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor

Jiao-Jiao Liu(刘娇娇)¹, Qi Chang(常琪)¹, Mei-Mei Bao(鲍美美)¹, Bing Yuan(元冰)¹, Kai Yang(杨恺)¹, Yu-Qiang Ma(马余强)^1,2

1 Center for Soft Condensed Matter Physics and Interdisciplinary Research, College of Physics, Optoelectronics and Energy, Soochow University, Suzhou 215006, China;
2 National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, China

Received:2017-05-04 Revised:2017-05-18 Online:2017-09-05 Published:2017-09-05
Contact: Bing Yuan, Kai Yang E-mail:yuanbing@suda.edu.cn;yangkai@suda.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 21374074, 21422404, and U1532108) and the Undergraduate Training Program for Innovation and Entrepreneurship of Soochow University, China (Grant No. 2016xj010).

摘要/Abstract

摘要：

Imaging-guided cancer therapy provides a simultaneous tumor imaging and treatment, which helps to eliminate the excessive toxicity to the healthy tissues. For this purpose, multifunctional probes capable of both imaging and curing are needed. In this work, we synthesize water-soluble silicon quantum dots (Si QDs) smaller than 5 nm. Such Si QDs are used for delivering the hydrophobic drug phthalocyanine (Pc). The as-prepared Si/Pc nanocomposite particles show efficient transmembrane delivery into cells and feasible biocompatibility. Moreover, these composite particles emit dual-channel fluorescence signals even after cellular internalization and demonstrate robust photostability in the Si channel. More interestingly, the Si/Pc composite particles show efficient photodynamic therapy effects against tumors both in vitro and in vivo.

关键词: silicon quantum dot, drug delivery, photodynamic therapy

Abstract:

Key words: silicon quantum dot, drug delivery, photodynamic therapy

中图分类号: (Nanoscale materials and structures: fabrication and characterization)

81.07.-b

62.23.-c (Structural classes of nanoscale systems)

刘娇娇, 常琪, 鲍美美, 元冰, 杨恺, 马余强. Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor[J]. 中国物理B, 2017, 26(9): 98102-098102.

Jiao-Jiao Liu(刘娇娇), Qi Chang(常琪), Mei-Mei Bao(鲍美美), Bing Yuan(元冰), Kai Yang(杨恺), Yu-Qiang Ma(马余强). Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor[J]. Chin. Phys. B, 2017, 26(9): 98102-098102.

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Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor

Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor

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