中国物理B ›› 2004, Vol. 13 ›› Issue (9): 1569-1573.doi: 10.1088/1009-1963/13/9/036

• 8000 CROSSDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇    下一篇

A model for processivity of molecular motors

谢平, 窦硕星, 王鹏业   

  1. Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China
  • 收稿日期:2003-09-09 修回日期:2004-03-18 出版日期:2005-06-21 发布日期:2005-06-21
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos 60025516 and 10334100).

A model for processivity of molecular motors

Xie Ping (谢平), Dou Shuo-Xing (窦硕星), Wang Peng-Ye (王鹏业)   

  1. Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China
  • Received:2003-09-09 Revised:2004-03-18 Online:2005-06-21 Published:2005-06-21
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos 60025516 and 10334100).

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摘要： We propose a two-dimensional model for a complete description of the dynamics of molecular motors, including both the processive movement along track filaments and the dissociation from the filaments. Theoretical results on the distributions of the run length and dwell time at a given adenosine triphosphate (ATP) concentration, the dependences of mean run length, mean dwell time and mean velocity on ATP concentration and load are in good agreement with the previous experimental results.

Abstract: We propose a two-dimensional model for a complete description of the dynamics of molecular motors, including both the processive movement along track filaments and the dissociation from the filaments. Theoretical results on the distributions of the run length and dwell time at a given adenosine triphosphate (ATP) concentration, the dependences of mean run length, mean dwell time and mean velocity on ATP concentration and load are in good agreement with the previous experimental results.

Key words: molecular motor, two-dimensional model, Brownian particle, Langevin equation

中图分类号:  (Proteins)

  • 87.14.E-
82.37.Np (Single molecule reaction kinetics, dissociation, etc.) 87.15.La (Mechanical properties)