中国物理B ›› 2004, Vol. 13 ›› Issue (7): 1171-1176.doi: 10.1088/1009-1963/13/7/037

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A nonequilibrium phase transition in immune response

漆安慎1, 张伟2   

  1. (1)Department of Physics, Beijing Normal University, Beijing 100875, China; (2)Department of System Science, Beijing Normal University, Beijing 100875, China
  • 收稿日期:2003-12-11 修回日期:2004-03-04 出版日期:2004-07-05 发布日期:2005-07-05
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant No 30070216).

A nonequilibrium phase transition in immune response

 Zhang Wei (张伟)a, Qi An-Shen (漆安慎)b   

  1. a Department of System Science, Beijing Normal University, Beijing 100875, China; b Department of Physics, Beijing Normal University, Beijing 100875, China
  • Received:2003-12-11 Revised:2004-03-04 Online:2004-07-05 Published:2005-07-05
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant No 30070216).

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摘要： The dynamics of immune response correlated to signal transduction in immune thymic cells (T cells) is studied. In particular, the problem of the phosphorylation of the immune-receptor tyrosine-based activation motifs (ITAM) is explored. A nonlinear model is established on the basis of experimental observations. The behaviours of the model can be well analysed using the concepts of nonequilibrium phase transitions. In addition, the Riemann－Hugoniot cusp catastrophe is demonstrated by the model. Due to the application of the theory of nonequilibrium phase transitions, the biological phenomena can be clarified more precisely. The results can also be used to further explain the signal transduction and signal discrimination of an important type of immune T cell.

关键词: nonequilibrium phase transitions, ITAM, cusp catastrophe

Abstract: The dynamics of immune response correlated to signal transduction in immune thymic cells (T cells) is studied. In particular, the problem of the phosphorylation of the immune-receptor tyrosine-based activation motifs (ITAM) is explored. A nonlinear model is established on the basis of experimental observations. The behaviours of the model can be well analysed using the concepts of nonequilibrium phase transitions. In addition, the Riemann－Hugoniot cusp catastrophe is demonstrated by the model. Due to the application of the theory of nonequilibrium phase transitions, the biological phenomena can be clarified more precisely. The results can also be used to further explain the signal transduction and signal discrimination of an important type of immune T cell.

Key words: nonequilibrium phase transitions, ITAM, cusp catastrophe

中图分类号:  (General studies of phase transitions)

  • 64.60.-i
87.17.Aa (Modeling, computer simulation of cell processes)