中国物理B ›› 2024, Vol. 33 ›› Issue (5): 58801-058801.doi: 10.1088/1674-1056/ad21f5
Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing
Haoran Yan(严浩然)1, Jiaqi Yan(颜家琦)1, Lianchun Yu(俞连春)1,2,†, and Yu-Feng Shao(邵玉峰)3
- 1 School of Physical Science and Technology, Lanzhou Center for Theoretical Physics, Lanzhou University, Lanzhou 730000, China;
2 Key Laboratory of Theoretical Physics of Gansu Province, and Key Laboratory of Quantum Theory and Applications of MoE, Lanzhou University, Lanzhou 730000, China;
3 Department of Neuroscience, Anatomy, Histology, and Embryology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing
Haoran Yan(严浩然)1, Jiaqi Yan(颜家琦)1, Lianchun Yu(俞连春)1,2,†, and Yu-Feng Shao(邵玉峰)3
- 1 School of Physical Science and Technology, Lanzhou Center for Theoretical Physics, Lanzhou University, Lanzhou 730000, China;
2 Key Laboratory of Theoretical Physics of Gansu Province, and Key Laboratory of Quantum Theory and Applications of MoE, Lanzhou University, Lanzhou 730000, China;
3 Department of Neuroscience, Anatomy, Histology, and Embryology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
摘要： The Hodgkin-Huxley model assumes independent ion channel activation, although mutual interactions are common in biological systems. This raises the problem why neurons would favor independent over cooperative channel activation. In this study, we evaluate how cooperative activation of sodium channels affects the neuron's information processing and energy consumption. Simulations of the stochastic Hodgkin-Huxley model with cooperative activation of sodium channels show that, while cooperative activation enhances neuronal information processing capacity, it greatly increases the neuron's energy consumption. As a result, cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing. This discovery improves our understanding of the design principles for neural systems, and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.
中图分类号: (Energy efficiency; definitions and standards)
- 88.05.Bc