Effect of applied electric fields on supralinear dendritic integration of interneuron

doi:10.1088/1674-1056/ad09cc

中国物理B ›› 2024, Vol. 33 ›› Issue (2): 20202-020202.doi: 10.1088/1674-1056/ad09cc

Effect of applied electric fields on supralinear dendritic integration of interneuron

Ya-Qin Fan(樊亚琴)¹, Xi-Le Wei(魏熙乐)¹, Mei-Li Lu(卢梅丽)², and Guo-Sheng Yi(伊国胜)^1,†

1 Tianjin Key Laboratory of Process Measurement and Control, School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China;
2 School of Information Technology Engineering, Tianjin University of Technology and Education, Tianjin 300222, China

收稿日期:2023-07-27 修回日期:2023-10-17 接受日期:2023-11-06 出版日期:2024-01-16 发布日期:2024-01-16
通讯作者: Guo-Sheng Yi E-mail:guoshengyi@tju.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 62171312) and the Tianjin Municipal Education Commission Scientific Research Project, China (Grant No. 2020KJ114).

Effect of applied electric fields on supralinear dendritic integration of interneuron

Ya-Qin Fan(樊亚琴)¹, Xi-Le Wei(魏熙乐)¹, Mei-Li Lu(卢梅丽)², and Guo-Sheng Yi(伊国胜)^1,†

1 Tianjin Key Laboratory of Process Measurement and Control, School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China;
2 School of Information Technology Engineering, Tianjin University of Technology and Education, Tianjin 300222, China

Received:2023-07-27 Revised:2023-10-17 Accepted:2023-11-06 Online:2024-01-16 Published:2024-01-16
Contact: Guo-Sheng Yi E-mail:guoshengyi@tju.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 62171312) and the Tianjin Municipal Education Commission Scientific Research Project, China (Grant No. 2020KJ114).

摘要/Abstract

摘要： Evidences show that electric fields (EFs) induced by the magnetic stimulation could modulates brain activities by regulating the excitability of GABAergic interneuron. However, it is still unclear how and why the EF-induced polarization affects the interneuron response as the interneuron receives NMDA synaptic inputs. Considering the key role of NMDA receptor-mediated supralinear dendritic integration in neuronal computations, we suppose that the applied EFs could functionally modulate interneurons' response via regulating dendritic integration. At first, we build a simplified multi-dendritic circuit model with inhomogeneous extracellular potentials, which characterizes the relationship among EF-induced spatial polarizations, dendritic integration, and somatic output. By performing model-based singular perturbation analysis, it is found that the equilibrium point of fast subsystem can be used to asymptotically depict the subthreshold input-output (sI/O) relationship of dendritic integration. It predicted that EF-induced strong depolarizations on the distal dendrites reduce the dendritic saturation output by reducing driving force of synaptic input, and it shifts the steep change of sI/O curve left by reducing stimulation threshold of triggering NMDA spike. Also, the EF modulation prefers the global dendritic integration with asymmetric scatter distribution of NMDA synapses. Furthermore, we identify the respective contribution of EF-regulated dendritic integration and EF-induced somatic polarization to an action potential generation and find that they have an antagonistic effect on AP generation due to the varied NMDA spike threshold under EF stimulation.

关键词: GABAergic interneuron, electrical field, supralinear dendritic integration, action potential generation

Abstract: Evidences show that electric fields (EFs) induced by the magnetic stimulation could modulates brain activities by regulating the excitability of GABAergic interneuron. However, it is still unclear how and why the EF-induced polarization affects the interneuron response as the interneuron receives NMDA synaptic inputs. Considering the key role of NMDA receptor-mediated supralinear dendritic integration in neuronal computations, we suppose that the applied EFs could functionally modulate interneurons' response via regulating dendritic integration. At first, we build a simplified multi-dendritic circuit model with inhomogeneous extracellular potentials, which characterizes the relationship among EF-induced spatial polarizations, dendritic integration, and somatic output. By performing model-based singular perturbation analysis, it is found that the equilibrium point of fast subsystem can be used to asymptotically depict the subthreshold input-output (sI/O) relationship of dendritic integration. It predicted that EF-induced strong depolarizations on the distal dendrites reduce the dendritic saturation output by reducing driving force of synaptic input, and it shifts the steep change of sI/O curve left by reducing stimulation threshold of triggering NMDA spike. Also, the EF modulation prefers the global dendritic integration with asymmetric scatter distribution of NMDA synapses. Furthermore, we identify the respective contribution of EF-regulated dendritic integration and EF-induced somatic polarization to an action potential generation and find that they have an antagonistic effect on AP generation due to the varied NMDA spike threshold under EF stimulation.

Key words: GABAergic interneuron, electrical field, supralinear dendritic integration, action potential generation

中图分类号: (Singularity theory)

02.40.Xx

02.60.Cb (Numerical simulation; solution of equations) 05.45.-a (Nonlinear dynamics and chaos)

Ya-Qin Fan(樊亚琴), Xi-Le Wei(魏熙乐), Mei-Li Lu(卢梅丽), and Guo-Sheng Yi(伊国胜). Effect of applied electric fields on supralinear dendritic integration of interneuron[J]. 中国物理B, 2024, 33(2): 20202-020202.

Ya-Qin Fan(樊亚琴), Xi-Le Wei(魏熙乐), Mei-Li Lu(卢梅丽), and Guo-Sheng Yi(伊国胜). Effect of applied electric fields on supralinear dendritic integration of interneuron[J]. Chin. Phys. B, 2024, 33(2): 20202-020202.

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Effect of applied electric fields on supralinear dendritic integration of interneuron

Effect of applied electric fields on supralinear dendritic integration of interneuron

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