中国物理B ›› 2022, Vol. 31 ›› Issue (3): 34302-034302.doi: 10.1088/1674-1056/ac1f01

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Nonlinear oscillation characteristics of magnetic microbubbles under acoustic and magnetic fields

Lixia Zhao(赵丽霞)1, Huimin Shi(史慧敏)1, Isaac Bello2, Jing Hu(胡静)1, Chenghui Wang(王成会)1, and Runyang Mo(莫润阳)1,†   

  1. 1 Shaanxi Key Laboratory of Ultrasonics, School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710119, China;
    2 Department of Chemistry, Ahmadu Bello University, Zaria 810001, Nigeria
  • 收稿日期:2021-04-30 修回日期:2021-08-08 接受日期:2021-08-19 出版日期:2022-02-22 发布日期:2022-02-17
  • 通讯作者: Runyang Mo E-mail:mmrryycn@snnu.edu.cn
  • 基金资助:
    The authors acknowledge the support of the National Natural Science Foundation of China (Grant Nos. 12074238 and 11974232).

Nonlinear oscillation characteristics of magnetic microbubbles under acoustic and magnetic fields

Lixia Zhao(赵丽霞)1, Huimin Shi(史慧敏)1, Isaac Bello2, Jing Hu(胡静)1, Chenghui Wang(王成会)1, and Runyang Mo(莫润阳)1,†   

  1. 1 Shaanxi Key Laboratory of Ultrasonics, School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710119, China;
    2 Department of Chemistry, Ahmadu Bello University, Zaria 810001, Nigeria
  • Received:2021-04-30 Revised:2021-08-08 Accepted:2021-08-19 Online:2022-02-22 Published:2022-02-17
  • Contact: Runyang Mo E-mail:mmrryycn@snnu.edu.cn
  • Supported by:
    The authors acknowledge the support of the National Natural Science Foundation of China (Grant Nos. 12074238 and 11974232).

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摘要： Microbubbles loaded with magnetic nanoparticles (MMBs) have attracted increasing interests in multimode imaging and drug/gene delivery and targeted therapy. However, the dynamic behaviors generated in diagnostic and therapeutic applications are not clear. In the present work, a novel theoretical model of a single MMB was developed, and the dynamic responses in an infinite viscous fluid were investigated under simultaneous exposure to magnetic and acoustic fields. The results showed that the amplitude reduces and the resonant frequency increases with the strength of the applied steady magnetic field and the susceptibility of the magnetic shell. However, the magnetic field has a limited influence on the oscillating. It is also noticed that the responses of MMB to a time-varying magnetic field is different from a steady magnetic field. The subharmonic components increase firstly and then decrease with the frequency of the magnetic field and the enhanced effect is related to the acoustic driving frequency. It is indicated that there may be a coupling interaction effect between the acoustic and magnetic fields.

关键词: magnetic microbubbles, ultrasound, magnetic field, nonlinear oscillation

Abstract: Microbubbles loaded with magnetic nanoparticles (MMBs) have attracted increasing interests in multimode imaging and drug/gene delivery and targeted therapy. However, the dynamic behaviors generated in diagnostic and therapeutic applications are not clear. In the present work, a novel theoretical model of a single MMB was developed, and the dynamic responses in an infinite viscous fluid were investigated under simultaneous exposure to magnetic and acoustic fields. The results showed that the amplitude reduces and the resonant frequency increases with the strength of the applied steady magnetic field and the susceptibility of the magnetic shell. However, the magnetic field has a limited influence on the oscillating. It is also noticed that the responses of MMB to a time-varying magnetic field is different from a steady magnetic field. The subharmonic components increase firstly and then decrease with the frequency of the magnetic field and the enhanced effect is related to the acoustic driving frequency. It is indicated that there may be a coupling interaction effect between the acoustic and magnetic fields.

Key words: magnetic microbubbles, ultrasound, magnetic field, nonlinear oscillation

中图分类号:  (Nonlinear acoustics)

  • 43.25.+y
43.35.+d (Ultrasonics, quantum acoustics, and physical effects of sound)