Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism

doi:10.1088/1674-1056/27/2/028702

中国物理B ›› 2018, Vol. 27 ›› Issue (2): 28702-028702.doi: 10.1088/1674-1056/27/2/028702

所属专题： TOPICAL REVIEW — Soft matter and biological physics

• SPECIAL TOPIC—Soft matter and biological physics (Review) • 上一篇下一篇

Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism

Shu-Yu Chen(陈淑玉), Na Li(李娜), Tao-Li Jin(金桃丽), Lu Gou(缑璐), Dong-Xiao Hao(郝东晓), Zhi-Qi Tian(田芷淇), Sheng-Li Zhang(张胜利), Lei Zhang(张磊)

Department of Applied Physics, Xi'an Jiaotong University, Xi'an 710049, China

收稿日期:2017-08-31 修回日期:2017-12-04 出版日期:2018-02-05 发布日期:2018-02-05
通讯作者: Lei Zhang E-mail:zhangleio@xjtu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11504287 and 11774279).

Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism

Shu-Yu Chen(陈淑玉), Na Li(李娜), Tao-Li Jin(金桃丽), Lu Gou(缑璐), Dong-Xiao Hao(郝东晓), Zhi-Qi Tian(田芷淇), Sheng-Li Zhang(张胜利), Lei Zhang(张磊)

Department of Applied Physics, Xi'an Jiaotong University, Xi'an 710049, China

Received:2017-08-31 Revised:2017-12-04 Online:2018-02-05 Published:2018-02-05
Contact: Lei Zhang E-mail:zhangleio@xjtu.edu.cn
About author:87.14.Cc; 87.14.E-; 87.15.H-; 87.64.Ee
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11504287 and 11774279).

摘要/Abstract

摘要：

Lipoproteins are protein-lipid macromolecular assemblies which are used to transport lipids in circulation and are key targets in cardiovascular disease (CVD). The highly dynamic lipoprotein molecules are capable of adopting an array of conformations that is crucial to lipid transport along the cholesterol transport pathway, among which high-density lipoprotein (HDL) and low-density lipoprotein (LDL) are major players in plasma cholesterol metabolism. For a more detailed illustration of cholesterol transport process, as well as the development of therapies to prevent CVD, here we review the functional mechanism and structural basis of lipoproteins in cholesterol transport, as well as their structural dynamics in the plasma lipoprotein (HDL and LDL) elevations, in order to obtain better quantitative understandings on structure-function relationship of lipoproteins. Finally, we also provide an approach for further research on the lipoprotein in cholesterol transport.

关键词: cholesterol transport, high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesteryl ester transfer protein (CETP)

Abstract:

Key words: cholesterol transport, high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesteryl ester transfer protein (CETP)

中图分类号: (Lipids)

87.14.Cc

87.14.E- (Proteins) 87.15.H- (Dynamics of biomolecules) 87.64.Ee (Electron microscopy)

陈淑玉, 李娜, 金桃丽, 缑璐, 郝东晓, 田芷淇, 张胜利, 张磊. Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism[J]. 中国物理B, 2018, 27(2): 28702-028702.

Shu-Yu Chen(陈淑玉), Na Li(李娜), Tao-Li Jin(金桃丽), Lu Gou(缑璐), Dong-Xiao Hao(郝东晓), Zhi-Qi Tian(田芷淇), Sheng-Li Zhang(张胜利), Lei Zhang(张磊). Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism[J]. Chin. Phys. B, 2018, 27(2): 28702-028702.

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Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism

Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism

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