中国物理B ›› 2006, Vol. 15 ›› Issue (7): 1526-1531.doi: 10.1088/1009-1963/15/7/025

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The viscoelasticity of lipid shell and the hysteresis of subharmonic in liquid containing microbubbles

龚燕君1, 章东1, 龚秀芬1, 谭开彬2, 刘政2   

  1. (1)Institute of Acoustics, Nanjing University, Nanjing 210093, China; (2)Xinqiao Hospital, Third Military Medical University,Chongqing 400037, China
  • 收稿日期:2005-12-17 修回日期:2006-02-02 出版日期:2006-07-20 发布日期:2006-07-20
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos 10274032 and 320200265), National Natural Science Foundation of Jiangsu Province, China (Grant No BK2004081).

The viscoelasticity of lipid shell and the hysteresis of subharmonic in liquid containing microbubbles

Gong Yan-Jun (龚燕君)a, Zhang Dong (章东)a, Gong Xiu-Fen (龚秀芬)a, Tan Kai-Bin (谭开彬)b, Liu Zheng (刘政)b   

  1. a Institute of Acoustics, Nanjing University, Nanjing 210093, China; b Xinqiao Hospital, Third Military Medical University,Chongqing 400037, China
  • Received:2005-12-17 Revised:2006-02-02 Online:2006-07-20 Published:2006-07-20
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos 10274032 and 320200265), National Natural Science Foundation of Jiangsu Province, China (Grant No BK2004081).

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摘要： The viscoelasticity and subharmonic generation of a kind of lipid ultrasound contrast agent are investigated. Based on the measurement of the sound attenuation spectrum, the viscoelasticity of the lipid shell is estimated by use of an optimization method. Shear modulus GS=10MPa and shear viscosity \mu S=1.49N\cdotS/m2 are obtained. The nonlinear oscillation of the encapsulated microbubble is studied with Church's model theoretically and experimentally. Especially, the dependence of subharmonic on the incident acoustic pressure is studied. The results reveal that the development of the subharmonic undergoes three stages, i.e. occurrence, growth and saturation, and that hysteresis appears in descending ramp insonation.

关键词: lipid shell, viscoelasticity, subharmonic, hysteresis

Abstract: The viscoelasticity and subharmonic generation of a kind of lipid ultrasound contrast agent are investigated. Based on the measurement of the sound attenuation spectrum, the viscoelasticity of the lipid shell is estimated by use of an optimization method. Shear modulus GS=10MPa and shear viscosity $\mu_{\rm S}$=1.49N$\cdot$S/m2 are obtained. The nonlinear oscillation of the encapsulated microbubble is studied with Church's model theoretically and experimentally. Especially, the dependence of subharmonic on the incident acoustic pressure is studied. The results reveal that the development of the subharmonic undergoes three stages, i.e. occurrence, growth and saturation, and that hysteresis appears in descending ramp insonation.

Key words: lipid shell, viscoelasticity, subharmonic, hysteresis

中图分类号:  (Lipids)

  • 87.14.Cc
43.80.Cs (Acoustical characteristics of biological media: molecular species, cellular level tissues) 87.15.La (Mechanical properties) 87.63.D- (Ultrasonography)