In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

doi:10.1088/1674-1056/21/7/074301

中国物理B ›› 2012, Vol. 21 ›› Issue (7): 74301-074301.doi: 10.1088/1674-1056/21/7/074301

• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇下一篇

In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

崔炜程^a, 屠娟^a, Hwang Joo-Ha^b, 李倩^a, 范庭波^a, 章东^a, 陈静海^c, 陈伟中^a

a Key Laboratory of Modern Acoustics, MOE, and Institute of Acoustics, Nanjing University, Nanjing 210093, China;
b Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105, USA;
c Department of Cardiology of Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA

收稿日期:2011-09-15 修回日期:2012-01-04 出版日期:2012-06-01 发布日期:2012-06-01
基金资助:
Project supported by the National Basic Research Program of China (Grant No. 2011CB707900), the National Natural Science Foundation of China (Grant Nos. 11074123, 10974095, 10904068, and 10204014), the Fundamental Research Funds for the Central Universities of China (Grant Nos. 111602040 and 1095020409), the Natural Science Foundation of Jiangsu Province of China (Grant No. BK2011812), and the Priority Academic Program Development of Jiangsu Higher Educaton Institutions of China.

In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

Cui Wei-Cheng(崔炜程)^a), Tu Juan(屠娟)^a)†, Hwang Joo-Ha^b), Li Qian (李倩)^a), Fan Ting-Bo(范庭波)^a), Zhang Dong(章东)^a), Chen Jing-Hai(陈静海)^c), and Chen Wei-Zhong(陈伟中)^a)

a Key Laboratory of Modern Acoustics, MOE, and Institute of Acoustics, Nanjing University, Nanjing 210093, China;
b Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105, USA;
c Department of Cardiology of Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA

Received:2011-09-15 Revised:2012-01-04 Online:2012-06-01 Published:2012-06-01
Contact: Tu Juan E-mail:juantu@nju.edu.cn
Supported by:
Project supported by the National Basic Research Program of China (Grant No. 2011CB707900), the National Natural Science Foundation of China (Grant Nos. 11074123, 10974095, 10904068, and 10204014), the Fundamental Research Funds for the Central Universities of China (Grant Nos. 111602040 and 1095020409), the Natural Science Foundation of Jiangsu Province of China (Grant No. BK2011812), and the Priority Academic Program Development of Jiangsu Higher Educaton Institutions of China.

摘要/Abstract

摘要： Hyperthermia effects (39--44 ℃) induced by pulsed high-intensity focused ultrasound (HIFU) have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU (1.17 MHz, 5300 W/cm², with relatively low-duty ratios (0.2%--4.3%). The results show that: (1) with constant pulse repetition frequency (PRF) (e.g., 1 Hz), the thermal responses inside the vessel will increase with the increasing duty ratio; (2) a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; (3) with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; (4) as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.

关键词: hyperthermia effects, high-intensity focused ultrasound, duty ratio, ultrasound contrast agents

Abstract: Hyperthermia effects (39--44 ℃) induced by pulsed high-intensity focused ultrasound (HIFU) have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU (1.17 MHz, 5300 W/cm², with relatively low-duty ratios (0.2%--4.3%). The results show that: (1) with constant pulse repetition frequency (PRF) (e.g., 1 Hz), the thermal responses inside the vessel will increase with the increasing duty ratio; (2) a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; (3) with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; (4) as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.

Key words: hyperthermia effects, high-intensity focused ultrasound, duty ratio, ultrasound contrast agents

中图分类号: (Nonlinear acoustics)

43.25.+y

43.35.+d (Ultrasonics, quantum acoustics, and physical effects of sound) 43.80.+p (Bioacoustics)

崔炜程, 屠娟, Hwang Joo-Ha, 李倩, 范庭波, 章东, 陈静海, 陈伟中 . In vivo hyperthermia effect induced by high-intensity pulsed ultrasound[J]. 中国物理B, 2012, 21(7): 74301-074301.

Cui Wei-Cheng(崔炜程), Tu Juan(屠娟), Hwang Joo-Ha, Li Qian (李倩), Fan Ting-Bo(范庭波), Zhang Dong(章东), Chen Jing-Hai(陈静海), and Chen Wei-Zhong(陈伟中) . In vivo hyperthermia effect induced by high-intensity pulsed ultrasound[J]. Chin. Phys. B, 2012, 21(7): 74301-074301.

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In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

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