Effect of secondary radiation force on aggregation between encapsulated microbubbles

doi:10.1088/1674-1056/20/11/114302

中国物理B ›› 2011, Vol. 20 ›› Issue (11): 114302-114302.doi: 10.1088/1674-1056/20/11/114302

Effect of secondary radiation force on aggregation between encapsulated microbubbles

汤孟兴¹, 郑海荣², 张艳丽³, 章东³

(1)Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK; (2)Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518067, China; (3)Key Laboratory of Modern Acoustics of Ministry of Education, Institute of Acoustics, Nanjing University, Nanjing 210093, China

收稿日期:2011-04-08 修回日期:2011-05-05 出版日期:2011-11-15 发布日期:2011-11-15
基金资助:
Project supported by the National Basic Research Program of China (Grant No. 2011CB707900), the National Natural Science Foundation of China (Grant Nos. 10974093, 11011130201, and 10904094), the Fundamental Research Funds for the Central Universities of China (Grant Nos. 1103020402, 1116020410, and 1112020401), the Prior Academic Program Development of Jiangsu Higher Education Institutions, China, and the State key Laboratory of Acoustics of Ministry of Education, China.

Effect of secondary radiation force on aggregation between encapsulated microbubbles

Zhang Yan-Li(张艳丽)^a), Zheng Hai-Rong(郑海荣)^b),Tang Meng-Xing(汤孟兴)^c), and Zhang Dong(章东)^a)^†

^a Key Laboratory of Modern Acoustics of Ministry of Education, Institute of Acoustics, Nanjing University, Nanjing 210093, China; ^b Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518067, China; ^c Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK

Received:2011-04-08 Revised:2011-05-05 Online:2011-11-15 Published:2011-11-15
Supported by:
Project supported by the National Basic Research Program of China (Grant No. 2011CB707900), the National Natural Science Foundation of China (Grant Nos. 10974093, 11011130201, and 10904094), the Fundamental Research Funds for the Central Universities of China (Grant Nos. 1103020402, 1116020410, and 1112020401), the Prior Academic Program Development of Jiangsu Higher Education Institutions, China, and the State key Laboratory of Acoustics of Ministry of Education, China.

摘要/Abstract

摘要： Secondary radiation force can be an attractive force causing aggregates of encapsulated microbubbles in ultrasonic molecular imaging. The influence of the secondary radiation force on aggregation between two coated bubbles is investigated in this study. Numerical calculations are performed based on four simultaneous differential equations of radial and translational motions. Results show that the secondary force can change from attraction to repulsion during approach, and stable microbubble pairs can be formed in the vicinity of resonant regions; the possibility of microbubble aggregations can be reduced by using low exciting amplitude, ultrasonic frequencies deviating from the resonant frequencies or microbubbles with small compressibility.

关键词: microbubbles, secondary radiation force, aggregation

Abstract: Secondary radiation force can be an attractive force causing aggregates of encapsulated microbubbles in ultrasonic molecular imaging. The influence of the secondary radiation force on aggregation between two coated bubbles is investigated in this study. Numerical calculations are performed based on four simultaneous differential equations of radial and translational motions. Results show that the secondary force can change from attraction to repulsion during approach, and stable microbubble pairs can be formed in the vicinity of resonant regions; the possibility of microbubble aggregations can be reduced by using low exciting amplitude, ultrasonic frequencies deviating from the resonant frequencies or microbubbles with small compressibility.

Key words: microbubbles, secondary radiation force, aggregation

中图分类号: (Acoustics of viscoelastic materials)

43.35.Mr

43.35.Wa (Biological effects of ultrasound, ultrasonic tomography)

张艳丽, 郑海荣, 汤孟兴, 章东. Effect of secondary radiation force on aggregation between encapsulated microbubbles[J]. 中国物理B, 2011, 20(11): 114302-114302.

Zhang Yan-Li(张艳丽), Zheng Hai-Rong(郑海荣), Tang Meng-Xing(汤孟兴), and Zhang Dong(章东) . Effect of secondary radiation force on aggregation between encapsulated microbubbles[J]. Chin. Phys. B, 2011, 20(11): 114302-114302.

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Effect of secondary radiation force on aggregation between encapsulated microbubbles

Effect of secondary radiation force on aggregation between encapsulated microbubbles

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