Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells

doi:10.1088/1674-1056/ab3af4

中国物理B ›› 2019, Vol. 28 ›› Issue (10): 108701-108701.doi: 10.1088/1674-1056/ab3af4

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇下一篇

Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells

1 Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing 401331, China;
2 Department of Physics, Xiamen University, Xiamen 361005, China;
3 Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, China;
4 Materials Science and Engineering, Arizona State University, Tempe, Arizona 85287, USA;
5 Division of Physical Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia;
6 Shenzhen Shengyuan Biotechnology Co., Ltd, Shenzhen 518060, China

收稿日期:2019-07-05 修回日期:2019-07-30 出版日期:2019-10-05 发布日期:2019-10-05
通讯作者: Junle Qu, Liyu Liu E-mail:jlqu@szu.edu.cn;lyliu@cqu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11674043 and 11604030), the Fundamental Research Funds for the Central Universities, China (Grant No. 2018CDJDWL0011), the Fundamental and Advanced Research Program of Chongqing, China (Grant No. cstc2018jcyjAX0338), and Arizona State University Start-up Funds, USA.

Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells

Ling Xiong(熊玲)¹, Yanping Liu(刘艳平)^1,2, Ruchuan Liu(刘如川)¹, Wei Yuan(袁伟)³, Gao Wang(王高)¹, Yi He(何益)¹, Jianwei Shuai(帅建伟)², Yang Jiao(焦阳)⁴, Xixiang Zhang(张溪祥)⁵, Weijing Han(韩伟静)⁶, Junle Qu(屈军乐)³, Liyu Liu(刘雳宇)¹

1 Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing 401331, China;
2 Department of Physics, Xiamen University, Xiamen 361005, China;
3 Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, China;
4 Materials Science and Engineering, Arizona State University, Tempe, Arizona 85287, USA;
5 Division of Physical Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia;
6 Shenzhen Shengyuan Biotechnology Co., Ltd, Shenzhen 518060, China

Received:2019-07-05 Revised:2019-07-30 Online:2019-10-05 Published:2019-10-05
Contact: Junle Qu, Liyu Liu E-mail:jlqu@szu.edu.cn;lyliu@cqu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11674043 and 11604030), the Fundamental Research Funds for the Central Universities, China (Grant No. 2018CDJDWL0011), the Fundamental and Advanced Research Program of Chongqing, China (Grant No. cstc2018jcyjAX0338), and Arizona State University Start-up Funds, USA.

摘要/Abstract

摘要：

Cancer cell motility and its heterogeneity play an important role in metastasis, which is responsible for death of 90% of cancer patients. Here, in combination with a microfluidic technique, single-cell tracking, and systematic motility analysis, we present a rapid and quantitative approach to judge the motility heterogeneity of breast cancer cells MDA-MB-231 and MCF-7 in a well-defined three-dimensional (3D) microenvironment with controllable conditions. Following this approach, identification of highly mobile active cells in a medium with epithelial growth factor will provide a practical tool for cell invasion and metastasis investigation of multiple cancer cell types, including primary cells. Further, this approach could potentially become a speedy (~hours) and efficient tool for basic and clinical diagnosis.

关键词: cancer metastasis, motility heterogeneity, three-dimensional microenvironment, invasion potential

Abstract:

Key words: cancer metastasis, motility heterogeneity, three-dimensional microenvironment, invasion potential

中图分类号: (Cancer)

87.19.xj

87.85.dh (Cells on a chip) 87.85.gj (Movement and locomotion)

熊玲, 刘艳平, 刘如川, 袁伟, 王高, 何益, 帅建伟, 焦阳, 张溪祥, 韩伟静, 屈军乐, 刘雳宇. Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells[J]. 中国物理B, 2019, 28(10): 108701-108701.

Ling Xiong(熊玲), Yanping Liu(刘艳平), Ruchuan Liu(刘如川), Wei Yuan(袁伟), Gao Wang(王高), Yi He(何益), Jianwei Shuai(帅建伟), Yang Jiao(焦阳), Xixiang Zhang(张溪祥), Weijing Han(韩伟静), Junle Qu(屈军乐), Liyu Liu(刘雳宇). Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells[J]. Chin. Phys. B, 2019, 28(10): 108701-108701.

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Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells

Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells

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