Dynamic instability of collective myosin II motors

doi:10.1088/1674-1056/25/11/118701

中国物理B ›› 2016, Vol. 25 ›› Issue (11): 118701-118701.doi: 10.1088/1674-1056/25/11/118701

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇下一篇

Dynamic instability of collective myosin II motors

Jin-Fang Li(李金芳), Zi-Qing Wang(汪自庆), Qi-Kun Li(李奇昆), Jian-Jun Xing(邢建军), Guo-Dong Wang(王国栋)

College of Science, Northwest A & F University, Yangling 712100, China

收稿日期:2016-05-11 修回日期:2016-07-05 出版日期:2016-11-05 发布日期:2016-11-05
通讯作者: Zi-Qing Wang E-mail:zqwang@nwafu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 11205123).

Dynamic instability of collective myosin II motors

Jin-Fang Li(李金芳), Zi-Qing Wang(汪自庆), Qi-Kun Li(李奇昆), Jian-Jun Xing(邢建军), Guo-Dong Wang(王国栋)

College of Science, Northwest A & F University, Yangling 712100, China

Received:2016-05-11 Revised:2016-07-05 Online:2016-11-05 Published:2016-11-05
Contact: Zi-Qing Wang E-mail:zqwang@nwafu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 11205123).

摘要/Abstract

摘要： Some kinds of muscles can oscillate spontaneously, which is related to the dynamic instability of the collective motors. Based on the two-state ratchet model and with consideration of the motor stiffness, the dynamics of collective myosin Ⅱ motors are studied. It is shown that when the motor stiffness is small, the velocity of the collective motors decreases monotonically with load increasing. When the motor stiffness becomes large, dynamic instability appears in the force-velocity relationship of the collective-motor transport. For a large enough motor stiffness, the zero-velocity point lies in the unstable range of the force-velocity curve, and the motor system becomes unstable before the motion is stopped, so spontaneous oscillations can be generated if the system is elastically coupled to its environment via a spring. The oscillation frequency is related to the motor stiffness, motor binding rate, spring stiffness, and the width of the ATP excitation interval. For a medium motor stiffness, the zero-velocity point lies outside the unstable range of the force-velocity curve, and the motion will be stopped before the instability occurs.

关键词: ratchet model, motor stiffness, dynamic instability, spontaneous oscillation

Abstract: Some kinds of muscles can oscillate spontaneously, which is related to the dynamic instability of the collective motors. Based on the two-state ratchet model and with consideration of the motor stiffness, the dynamics of collective myosin Ⅱ motors are studied. It is shown that when the motor stiffness is small, the velocity of the collective motors decreases monotonically with load increasing. When the motor stiffness becomes large, dynamic instability appears in the force-velocity relationship of the collective-motor transport. For a large enough motor stiffness, the zero-velocity point lies in the unstable range of the force-velocity curve, and the motor system becomes unstable before the motion is stopped, so spontaneous oscillations can be generated if the system is elastically coupled to its environment via a spring. The oscillation frequency is related to the motor stiffness, motor binding rate, spring stiffness, and the width of the ATP excitation interval. For a medium motor stiffness, the zero-velocity point lies outside the unstable range of the force-velocity curve, and the motion will be stopped before the instability occurs.

Key words: ratchet model, motor stiffness, dynamic instability, spontaneous oscillation

中图分类号: (Motor proteins (myosin, kinesin dynein))

87.16.Nn

李金芳, 汪自庆, 李奇昆, 邢建军, 王国栋. Dynamic instability of collective myosin II motors[J]. 中国物理B, 2016, 25(11): 118701-118701.

Jin-Fang Li(李金芳), Zi-Qing Wang(汪自庆), Qi-Kun Li(李奇昆), Jian-Jun Xing(邢建军), Guo-Dong Wang(王国栋). Dynamic instability of collective myosin II motors[J]. Chin. Phys. B, 2016, 25(11): 118701-118701.

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Dynamic instability of collective myosin II motors

Dynamic instability of collective myosin II motors

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