中国物理B ›› 2015, Vol. 24 ›› Issue (8): 80701-080701.doi: 10.1088/1674-1056/24/8/080701

• GENERAL • 上一篇    下一篇

Molecular modeling of oscillating GHz electric field influence on the kinesin affinity to microtubule

H. R. Saeidia, S. S. Setayandeha, A. Lohrasebia b   

  1. a Department of Physics, University of Isfahan, Isfahan, Iran;
    b Computational Nano-Bioelectromagnetics Research Group, School of Nano-Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
  • 收稿日期:2014-09-24 修回日期:2015-03-14 出版日期:2015-08-05 发布日期:2015-08-05

Molecular modeling of oscillating GHz electric field influence on the kinesin affinity to microtubule

H. R. Saeidia, S. S. Setayandeha, A. Lohrasebia b   

  1. a Department of Physics, University of Isfahan, Isfahan, Iran;
    b Computational Nano-Bioelectromagnetics Research Group, School of Nano-Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
  • Received:2014-09-24 Revised:2015-03-14 Online:2015-08-05 Published:2015-08-05
  • Contact: A. Lohrasebi E-mail:lohrasebi@nano.ipm.ac.ir

摘要: Kinesin is a microtubule-associated motor protein which can respond to the external electric field due to its polarity. Using a molecular dynamics simulation method, the effect of such a field on the affinity of kinesin to the αβ-tubulin is investigated in this study. To consider kinesin affinity, the system is exposed to an electric field of 0.03 V/nm with frequency values of 1, 2,..., 9, and 10 GHz. It is found that the applied electric field can change kinesin affinity to the microtubule. These changes could perturb the normal operation of kinesin, such as the processive motility of kinesin on the microtubule.

关键词: kinesin affinity, oscillating electric field, molecular dynamic, αβ-tubulin dimer

Abstract: Kinesin is a microtubule-associated motor protein which can respond to the external electric field due to its polarity. Using a molecular dynamics simulation method, the effect of such a field on the affinity of kinesin to the αβ-tubulin is investigated in this study. To consider kinesin affinity, the system is exposed to an electric field of 0.03 V/nm with frequency values of 1, 2,..., 9, and 10 GHz. It is found that the applied electric field can change kinesin affinity to the microtubule. These changes could perturb the normal operation of kinesin, such as the processive motility of kinesin on the microtubule.

Key words: kinesin affinity, oscillating electric field, molecular dynamic, αβ-tubulin dimer

中图分类号:  (Computer modeling and simulation)

  • 07.05.Tp
76.60.-k (Nuclear magnetic resonance and relaxation) 87.15.R- (Reactions and kinetics) 87.10.Tf (Molecular dynamics simulation)